Klain, a well-known Democratic strategist, had also held the same job for former Vice President Al Gore. A close adviser to Obama, he had been recently mentioned as a possible replacement for Rahm Emanuel, who quit as the president's chief of staff in October.
According to the White House, Klain is leaving to become president of Case Holdings, an investment firm founded by former AOL chief Steve Case.
In a statement, Biden praised his outgoing staffer for an "exceptional job" and for providing "invaluable counsel" over the last two years.
"He has also played a key role in establishing the strong, positive relationship that exists between my staff and the president's team," Biden said. "I am proud of the successes we have had over these two years, and am grateful for the role Ron played in achieving them."
(Photo of Klain, center, and Obama by Pete Souza/White House)
- President Obama
- Ron Klain
- Rahm Emanuel
- Vice President Biden
- Vice President Al Gore
- the White House
- Steve Case