Christina Applegate is departing her NBC comedy, "Up All Night."
"It's been a great experience working on 'Up All Night', but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors," Christina said in a statement on Friday. "Working with Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always."
In Season 1 of the show, Christina played working mom Reagan Brinkley, who was a producer on a fictional talk show - "Ava" - hosted by Maya Rudolph's character. Season 2 changed things up with Maya's character now a former talk show host, and Christina's Reagan adjusting to being a stay-at-home mom.
The comedy also stars Will Arnett as Reagan's husband, Chris.
NBC would not comment on the news, when contacted by Access Hollywood on Friday.
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