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    Heart Failure, Diabetes Might Be Linked by Protein

    HealthDay – Thu, Jan 5, 2012

    THURSDAY, Jan. 5 (HealthDay News) -- Researchers may have pinpointed how heart disease can lead to diabetes, a finding that could lead to new preventive treatments.

    The team at Chiba University in Japan found that the stress of heart failure activates a protein called p53, resulting in inflammation in fat tissue, systemic insulin resistance and worsening heart function.

    This domino effect is outlined in a study in the January issue of the journal Cell Metabolism.

    "Our findings clarify the reasons why the incidence of heart failure is high among diabetic patients, why the prevalence of insulin resistance is increased in heart failure patients and why treatment of insulin resistance improves the prognosis of heart failure patients," study author Tohru Minamino said in a journal news release.

    Previous research by the author has shown that build-up of p53 in the heart -- from stress or age -- promotes heart failure, the release said. While p53 is best known as a tumor suppressor, it is also a cellular aging agent, according to Minamino. He explained that constant activation of p53 can lead to inflammation and aging-related diseases.

    Finding a way to block inflammation associated with p53 activation without compromising the protein's tumor-fighting abilities could lead to anti-aging therapy without the cancer risk, Minamino said.

    More information

    The U.S. National Diabetes Education Program outlines how you can prevent diabetes.

     

    11 comments

    • Neophyte
      Neophyte  •  4 mths ago
      Stories like this make me want to go into research...I want help find cures.
      • X
        X 4 mths ago
        stop drinking soda and eating trash and exercise. thats the cure
      • Neophyte
        Neophyte 4 mths ago
        Wow. The level of ignorance. What about type 1 diabetes? That's something you're born with.
      • pretensed
        pretensed 4 mths ago
        X, you obviously know nothing about diabetes. I battled for 2 decades to stay off the meds. I don't drink soda, gave that up 2 decades ago when they diagnosed me being border line and that I would be insulin dependent within five years. I don't eat trash, as you call it. Eventually, the pancreas stops producing what's needed to break down even the good carbs. I now have to take 2 pills everyday. Yes, eating right and exercising can help a diabetic stay healthier longer, but it will not cure one of the disease.
    • Granny
      Granny  •  Texarkana, Texas  •  4 mths ago
      Take care of yourself if you have diabetes...I had it for 13 years and was on Actos...
      so now I've been on dialysis 3 years. Believe me, it is the worst treatment system you
      could ever imagine. Every other day you're stuck in an uncomfortable chair for 4 hours
      and unable to do anything, with 2 huge needles stuck in one arm and a blood pressure
      cuff on the other. Hindsight is 20-20!
      • ellquestion authority
        ellquestion authority 4 mths ago
        living will. advanced medical directives would have kept you off the machine. why live sick all the time, quality vs. quantity. already have my living will and amd in place, no dialysis under any conditions. type 1 diabetic.
    • Michael B
      Michael B  •  4 mths ago
      I've been diabetic for eight years now on insulin and haven't seen a Doctor in seven. I can't find a full time job with insurance, nor find insurance. I take care of myself the best I can and do check my sugar obsessively. What a great country I live in.
      • .
        . 4 mths ago
        How do you get your insulin if you have not seen a Doctor?
      • ellquestion authority
        ellquestion authority 4 mths ago
        how can you afford all those test strips? insulin requires a prescription. liar.
      • pretensed
        pretensed 4 mths ago
        Diabetes is on the list to qualify for SSD or SSI. So, why lie about it. All that stuff you mentioned is very costly without insurance. I know, I'm diabetic.
    • gamawmarilyn
      gamawmarilyn  •  Willoughby, Ohio  •  4 mths ago
      I was diagnosed more than 4 yrs ago ...Thought I could beat the system. Its called denial especially with what I was eating. No more denial now,,, If I end up with a sore,,, it takes forever to h eal, neuropathy has set in with the feet and there are many frequent trips to the throne room. I wish I had listened both to friends and especially to my doctor who warned me many times. Now,,, I am having much difficulty walking and am very very overweight. Its a hellish disease,,,, so if there are those of you out there just in the beginning stages or have been told you are pre-diabetic,, get on the stick and do not mess with it. Its deadly and trust me when I tell you,,, it can be dealt with if gotten early enough. Please.... do yourself and your loved ones a favor and do all you can. Educate yourself, take the classes that many hospitals offer, and just maybe you will will be one of the lucky ones who escapes its ravages.
    • BoredStiff
      BoredStiff  •  4 mths ago
      If you need a Guinea Pig, I'm volunteering. Diabetes is a horrible disease, having been diagnosed with it over 20 years ago. I would do anything to be free from it.
    • justme
      justme  •  4 mths ago
      Skeptical of this. I was diagnosed with heart failure 11 years ago and I am NOT diabetic.
      • teio
        teio 4 mths ago
        It saids there might be a link. Heart failure can lead to diabetes. That does not mean everyone who has heart failure will develop diabetes. You just have an increased risk. Further research will be needed, and there are a lot of factors to consider in the real world. Not every person with heart failure is the same or have the same outcomes.
    • dawna
      dawna  •  Springfield, Missouri  •  4 mths ago
      My husband had diabetes for 20 years and passed away at the age of 54 from heart failure. The doctors never checked his heart until it was working at less than 10%. You need to look up all the info you can so you can ask the right questions ,we didnt know about the heart connection until it was to late and he needed a heart. My husband lived for 6 mo. after they told us he needed a heart.
    • Boo
      Boo  •  4 mths ago
      The "diabetes" discussed here is diabetes mellitus, not type 2. These people (often sedentary, overweight candidates for heart disease) have become insulin resistant over time. The P53 protein could be responsible for the diabetes TRIGGERED by the heart failure.
    • A-Nony-Mouse
      A-Nony-Mouse  •  Bozeman, Montana  •  4 mths ago
      gout cottonseed oil
      detached retena palm seed oil
    • A-Nony-Mouse
      A-Nony-Mouse  •  Bozeman, Montana  •  4 mths ago
      another addition of the truth.
      heart disease is caused by salt, garlic, smoke, raspberries, the mixture for sure wheat posssibly fruit pectin, peanuts, and the first list
      this is all prenatal
      a weak heart salt
      strong heart garlic--unsure if one mass does of g arlic without salt cancels many salt uses
      smoke cancels the mix of garlic and salt causing high blood pressure. too much smoke could be hemophilia.
      raspberries varicose veins cancel hardening of the arteries from mix of all three garlic salt and smoke.
      a whole in the heart could be peanut butter and jelly sammiches or pretzels.
      diabetes is caused from sugar thin umbilical cord (careful you can fix it but then it might hang)
      glaucoma is caused from sugar and maple mixed
      skinny diabetes and can be still birth is caused by maple syrup (not corn syrup) thick umbilical cord
      skin cancer wheat and maple
      • Mary
        Mary 4 mths ago
        What are you taking about!! Confused!!
      • Wixis
        Wixis 4 mths ago
        What is your drug of choice?! Uhhhh. Eat much potted meat, biscuits with mustard,fried 'taters with mustard? Uhhh. Heard that Southern Fried Glimps are great with mustard. Good 'ol pickeled pigs peters 'ur good with mustard.too. Eat lots of food and make a big turd!. Uhhh. Heard about some Chinese feller, makes burgers out of turds...somehows. I don't know, raspberries gives me the rasberries! Garlic is fer bad breath. #$%$ #$%$ can a carrrot do it fer 'ya.....how about a crooked neck squash? .......Had a dog once....do'nt remember it's name now. Writting from the mental institution....They let me write. Karl Chiders is my only friend.....only had to kill 'em with ' muh sling blade.....I dunno, a'int seem 'em since. Any-hoo enjoy some potted meat and mustard....bisquits and mustard is good too! Yep, skin cancer wheat and maple. uhhhh. Yep, 'yer #$%$ horribilus. The smoke part....uhhhh thunk,,,,nuff had. Uhhhh....you stupid -don't know a squirrel from .... This is Karl Childers.....what 'ya done kill me fer? Wht 'ya done kill me Fer? Be careful 'cus 'uh might be hung...prenatal......I like the way you crazy...you like the way I'm crazy? Can I put my arm around you?
    • Cory Morr
      Cory Morr  •  Fort Myers, Florida  •  4 mths ago
      Um... no... Carbohydrates. Sugars (Glucosamine) that keeps your hemoglobin (red blood cell count high) heathy and strong. It's converted into energy then are burned off. They are turned to waste in your kidneys that keep your digestive system clean. Ever heard of Monosaccharides and Triglycerides? If your pancreas can't periodically produce a sufficient amount of daily blood sugar intake your too low on blood sugar. Resulting in a balanced non-carb meal. 3x a day to elevate glucose blood cells.
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