Forestry officials were forced to flee, dive for cover and even climb up on a jeep to escape the adult, male leopard's attacks in West Bengal state.
At one point, the big cat leapt through the air, fangs bared, and tackled a man, clutching him in its giant paws as it knocked him off the wall he was standing on.
The wildlife officials — wearing protective helmets and carrying batons and tranquilizer guns — had hoped to drive the cat into a nearby wildlife sanctuary after it wandered into the village near Siliguri, about 373 miles (600 kilometers) from Kolkata.
But the leopard stood its ground, crouching on a wall, hissing and attacking those who came near.
It injured six villagers, a policeman and four forest guards before being hit with a tranquilizer gun Tuesday. The people are recovering from their injuries, mostly swipes from the cat's claws.
Forest official Dharma Dev Rai says villagers used knives, stones and batons to beat back the cat.
The cat died within hours after the showdown, and a post mortem is being conducted.
Leopards are protected in India, though more are straying into villages for food.