Take a look at some of Wednesday's midday movers:

Royal Caribbean Cruises (RCL) - The cruise operator and others including Carnival (CCL) and Norwegian Cruise Lines Holdings (NCLH) climbed on anticipation that a thaw in U.S.-Cuban relations will increase travel between the two countries.

Herzfeld Caribbean Basin Fund (CUBA) - The fund with $25 million in assets soared on news of the thaw in U.S.-Cuban relations.

Netflix (NFLX) - The provider of online entertainment rose after Dish Network (DISH) said it would begin streaming Netflix movies and TV shows.

Exxon Mobil (XOM) - The oil producer and competitors including Chevron (CVX) ConocoPhillips (COP), Hess (HES) and Anadarko Petroleum (APC) rallied with crude.

OnDeck Capital (ONDK) - The online arranger of small business loans soared in its market debut.

Amgen (AMGN) - The drug developer climbed after it said its new leukemia treatment would cost about $178,000 when it becomes available on Thursday.

NPS Pharmaceuticals (NPSP) - The drug developer gained after Bloomberg reported Shire (London Stock Exchange: SHP-GB) was considering a bid for the company.

Blackberry (Toronto Stock Exchange: BB-CA) - The maker of wireless devices advanced after it launched its long-awaited Classic smartphone device.

American Express (AXP) - The credit-card company rose after Morgan Stanley began coverage with an overweight rating.

MasterCard (MA) - The company and Visa (NYSE:V) advanced on news that credit and debit cards can now be used in Cuba.

Diageo (London Stock Exchange: DGE-GB) - The spirit maker fell after giving a lukewarm outlook for the first half of its fiscal year in the U.S.

Auspex Pharmaceuticals (ASPX) - The drug developer surged after saying said its drug for treating chorea, or involuntary movement associated with Huntington's disease, succeeded in a late-stage study.

Digital River (DRIV) - The provider of cloud-based payment solutions rose after it extended a distribution pact with Microsoft (MSFT).

The Pantry (PTRY) - The convenience-store chain jumped on a Wall Street Journal report that it was nearing a deal to sell itself.

Joy Global (JOY) - The mining-equipment maker fell after reporting a four percent drop in quarterly revenue.

Pozen (POZN) - The company declined after it said two versions of its experimental heart drug were rejected for a second time by the Food and Drug Administration.

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