MASON, Ohio (AP) — Andy Murray's off-day turned into the biggest upset of the Western & Southern Open on Thursday, a straight-set loss that left him with little hard-court experience heading into the U.S. Open.
Murray lost 6-4, 6-4 to France's Jeremy Chardy, an opponent he'd beaten easily the four previous times they'd played. Chardy reached the quarterfinals with steady play, while Murray had trouble controlling his shots on a hot and breezy afternoon.
"I was a little bit uncomfortable with those balls bouncing extremely high," said Murray, who left the court as soon as the match ended and headed directly to the interview room. "It was fairly hard to control."
Roger Federer, Mardy Fish and Juan Martin del Potro also reached the quarterfinals on Thursday.
Serena Williams won her 19th straight match — her last 12 in straight sets — by beating Urszula Radwanska of Poland 6-4, 6-3. Williams hasn't lost a set since the Wimbledon final, which she won.
She returned to Wimbledon and won the gold medal in singles and in doubles with sister Venus. On Wednesday, she felt a little drained in the 85-degree heat.
"I have been playing a lot," she said. "Definitely (need) more energy. Been traveling a lot, been training a lot. You know, it's been a really big summer."
Murray also won the gold medal at Wimbledon, the highlight of his career. He went to Toronto last week hoping to get in shape for the hard-court season, but had to withdraw from the Rogers Cup because his left knee started hurting in the transition from grass.
He felt good and moved well in an opening two-set win on center court Wednesday. Playing on the grandstand court a day later, he never got into a rhythm and repeatedly wasted chances to break Chardy, who had won only one set against him in their four previous matches.
Now, Murray heads to New York to practice for the U.S. Open, having played only three matches on hard courts since returning from Wimbledon's grass.
"I won't play any more matches," Murray said. "When going into the big tournaments, sometimes I've won tournaments in the buildup and it hasn't helped me. This year at Wimbledon, I lost in the first round at Queen's and made the final there for the first time. I have won Queen's before and not done well at Wimbledon.
"So it doesn't normally have that much bearing. But obviously I would have liked to have done a bit better this week."
Chardy got into the tournament as a replacement for John Isner, who had a sore back. The Frenchman had a straight-set victory on Tuesday over Andy Roddick, who developed back spasms during the match.
Federer beat Bernard Tomic 6-2, 6-4 and has looked sharp in his two hard-court matches since losing to Murray in the gold medal match. Federer skipped the Rogers Cup last week.
Fish, a two-time runner-up at the tournament in suburban Cincinnati, beat Radek Stepanek 6-3, 6-3, his first win over the Czech in five career matches. Fish celebrated his win with a leaping right fist pump after Stepanek's backhanded drop shot hit the net on match point.
"That was the monkey jumping off my back," Fish said. "He's been a tough opponent for me. Not only has he beaten me, but he's beaten me soundly."
Fish said the difference this time was his physical condition. He continues to improve after undergoing surgery in May to repair a heart condition.
"I feel fresher, stronger," he said. "The summer's gone well for me as far as getting my match fitness back."
The American hasn't dropped a set and has been broken only once while reaching the quarterfinals.
Serbia's Viktor Troicki took del Potro to three sets before fading. The Argentine improved to 6-0 in his career against Troicki with a 7-6 (2), 2-6, 6-1 win.
On the women's side, top-seeded Agnieszka Radwanska overcame an unexpected challenge from wild-card Sloane Stephens before winning 6-1, 4-6, 6-4. Radwanska, who lost to Serena Williams in the Wimbledon final, reached the tournament's quarterfinal for the first time in three appearances.
Like Murray, she had trouble with the condition on the grandstand court.
"It was so hot and windy," she said. "I think that this court was slower than the center (court) and the ball didn't go at all. I was hitting as much as I could, but it just was hard to make winners there."
Germany's Angelique Kerber also advanced with a 6-4, 7-6 (5) win over qualifier Andrea Hlavackova of the Czech Republic.
AP freelancer Mark Schmetzer contributed to this report.