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    Scientists May Be Closer to Developing 'Red Wine' Drug

    HealthDay – Thu, Feb 2, 2012

    THURSDAY, Feb. 2 (HealthDay News) -- U.S. researchers believe they've discovered how resveratrol -- a chemical found in red wine and other plant products -- provides health benefits.

    The researchers said their work with mice may help settle the debate about resveratrol's biochemistry and could advance efforts to develop resveratrol-based medicines.

    "Resveratrol has potential as a therapy for diverse diseases such as type 2 diabetes, Alzheimer's disease and heart disease," study author Dr. Jay Chung, chief of the Laboratory of Obesity and Aging Research at the National Heart, Lung and Blood Institute, said in an institute news release. "However, before researchers can transform resveratrol into a safe and effective medicine, they need to know exactly what it targets in cells."

    Resveratrol appears to inhibit proteins called phosphodiesterases (PDEs), which help regulate cell energy, according to the researchers.

    Some previous studies suggested that resveratrol's primary target is sirtuin 1, but the authors of this new study doubted that when they found that resveratrol activity required another protein called AMPK. This would not be the case if resveratrol directly interacted with sirtuin 1.

    The researchers analyzed the metabolic activity in cells treated with resveratrol and identified the protein PDE4 in the skeletal muscle as the principal target for the health benefits of resveratrol.

    Follow-up tests with mice confirmed that resveratrol attaches to and inhibits PDE proteins.

    The findings are published in the Feb. 3 issue of the journal Cell.

    Results from animal research are not necessarily applicable to humans. Much more research is needed before resveratrol drugs could be developed.

    More information

    The U.S. National Cancer Institute discusses red wine and cancer prevention.

     

    5 comments

    • The John
      The John  •  Falls Church, Virginia  •  3 mths ago
      I think I'll just drink wine rather than some friggin chemical.
    • Johnny
      Johnny  •  3 mths ago
      Almost every time that scientists extract a particular component from a food/plant, the concentrated and isolated compound is highly toxic in other ways. Why do we need to create a red wine drug when people can simply have a glass of red wine? Scientists have synthesized Marinol which is a form of THC as is found in marijuana, yet Marinol can kill and marijuana has never been the direct result of any human death in all of recorded human history!
    • Beverly
      Beverly  •  Westfield, Massachusetts  •  3 mths ago
      Ahhh so the next step will be to take red wine off the market because it's "dangerous" then all the pharm companies can make the money, right?
    • John
      John  •  3 mths ago
      The pill will work just fine, as long as you take it with a glass of red wine.
    • SanJuanKid
      SanJuanKid  •  3 mths ago
      You know how expensive a new 'red wine' drug will be, so just stick to Two-Buck Chuck.
     Post a comment
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