In 2022, some longtime favorite Jacksonville restaurants have closed. Here's a list.

In 2021, it was The Wine Cellar, River City Brewing Co., Mediterrania Restaurant.

In 2022, more Jacksonville-area restaurants are following suit, calling it quits after 10, 20 or even 30 years or more.

It's all part of the natural cycle of the business: People retire, new opportunities arise, business slows.

Even as effects of the pandemic linger, including labor shortages, supply chain issues and now, inflation, dozens of new restaurants are in the works all across Jacksonville.

Still, it can be hard to say goodbye to old favorites.

Here's a look at some of the notable restaurant closings of 2022.

From Arden's to Wine Cellar to Zodiac: These Jacksonville-area restaurants closed in 2021

Blackstone Grille

112 Bartram Oaks Walk, Saint Johns

A popular destination for dinner and celebrations for 15 years, Blackstone Grille closed after Father's Day dinner service on June 19. Chef Charles Wang, an award-winning chef with more than 30 years of experience, and his wife, Helen Chang, opened the restaurant in 2007, offering innovative interpretations of American cuisine plus the "best of flavors and tastes from a variety of cultures and influences" creating a taste best described as Modern American Fusion.

'It is bittersweet, but we are retiring': After 15 years, Blackstone Grille set to close in Saint Johns

Clark's Fish Camp

12903 Hood Landing Road

A fixture on Julington Creek since 1974, Clark's Fish Camp was listed for sale in October after temporarily closing a month earlier. The storied fish camp was known for its steak and seafood entrees, including Mayport peel-and-eat shrimp, clams, snow crab, oysters and more as well as a number of selections you won’t find on many menus in Jacksonville: frog legs, gator ribs, snake, kangaroo, turtle and “Bison Mountain Oysters.” For others, it was best known for what it says is the “largest public taxidermy collection in the United States” of big cats, small game and more. The decision to sell followed a series of flooding events in recent years as well the effects of the pandemic that left the restaurant "literally and figuratively underwater," its manager said.

'Literally and figuratively underwater': Landmark waterfront seafood restaurant in Jacksonville up for sale

European Street (Southside)

5500 Beach Blvd.

In mid-April, European Street Cafe closed its Southside location at 5500 Beach Blvd., where it had operated since March 1999. The restaurant, like three other locations that remain open, was known for its deli-style sandwiches, German-influenced entrees, soups, salads and sausages as well as its tempting dessert case and an even more tempting beer selection. The restaurants also feature imported beer and wine as well as a large selection of gourmet food. The 6,146-square-foot restaurant on 1.64 acres with frontage on Beach Boulevard was listed for sale for $1.4 million. European Street's three other locations remain open at 2753 Park St. in Riverside; 1704 San Marco Blvd. in San Marco; and 992 Beach Blvd. in Jacksonville Beach.

'The time has come': After 23 years, European Street closes Southside Jacksonville restaurant

German Schnitzel Haus

13245 Atlantic Blvd.

After 16 years of serving pork, veal and chicken schnitzels, sauerbraten, bratwurst platter, rindsrouladen and other authentic German cuisine, German Schnitzel Haus closed in mid-March at its Intracoastal West location. "With a heavy heart, after 16 years in business, German Schnitzel Haus is closing. During that time we have had the great pleasure of serving our lovely customers many of whom have become great friends. We have also been blessed with wonderful employees …Thanks to all for your longstanding support," an Instagram post said.

Auf Wiedersehen: After 16 years, German Schnitzel Haus restaurant abruptly closes

Liberty Bakery

6661 Bowden Road

Nine years after owners Bob and Carol Kernan first began serving up freshly baked cinnamon rolls, sticky buns, scones and muffins along with hand-crafted sandwiches and more, the 500-square-foot bakery located in a former Skinner Dairy store is set to close. "After 9 years of having the privilege of serving you, Bob and I have prayerfully decided to end our time at Liberty Bakery at the close of business on Saturday, Sept. 3," Carol Kernan wrote.

'Thank you for letting us into your lives': Liberty Bakery, a family-owned drive-thru bakery and sandwich shop, closing after 9 years

The Loop

4413 Town Center Parkway North

In early November, The Loop closed at the Town Center after company officials chose not to renew its lease. When it opened in December 2012, the restaurant served as a prototype for the Jacksonville-based chain's future, featuring a new design for the fast-casual restaurant founded in 1981. A decade later, the restaurant no longer fit into The Loop's future plans, the company's chief marketing official told the Times-Union. "We have decided to concentrate on other areas that are better suited for our concept moving forward." And that includes a new location coming in the first quarter of 2023. (Stay tuned.) After the closing, The Loop still has 10 locations in Northeast Florida and another five in North Carolina.

'We've appreciated our time here': After a decade, St. Johns Town Center restaurant abruptly closes

Monroe's Smokehouse Bar-B-Q & Catering

10771 Beach Blvd.

A decade after opening, Monroe's Smokehouse Bar-B-Q & Catering closed its Beach Boulevard restaurant in late August. (The original restaurant at 4838 Highway Ave. remains open.) In announcing the planned closure, owner Keith Monroe Waller wrote: "We have survived the worst of the pandemic, rising overhead and operational cost, labor shortages but it was an unforeseen major building repair cost that played a role in us having to make the exceedingly difficult decision."

'With great sadness': Monroe's Smokehouse announces plans to close Southside restaurant

Ocean 60

60 Ocean Blvd., Atlantic Beach

Known for its unique take on continental cuisine, including local-caught seafood fresh off the boats at Mayport, Ocean 60 closed in May after 20 years. Chef Daniel Groshell opened Ocean 60 in February 2002 at the former Nancy’s spot at 60 Ocean Blvd., and expanded a year later with the addition of The Martini Room. After 16 years, he sold the restaurant in 2018. Miami-based Salumeria 104, a trattoria-style restaurant specializing in salumi plates and traditional homemade Italian dishes, plans to take over the spot.

A favorite for 20 years: Atlantic Beach restaurant and wine bar Ocean 60 closes

Olio

301 E. Bay St.

Saying personal health issues left him no choice but to close, executive chef and owner Greg DeSanto closed his downtown lunch spot Olio in mid-March. The restaurant -- popular among downtown's office workers, city power brokers, politicians, doctors, cops and lawyers -- had operated at the location for 11 years. In 2012, just a year after its opening, Olio's Duck Grilled Cheese Sandwich was featured on the Travel Channel program "Adam Richman's Best Sandwich in America."  DeSanto said he hopes to return to the industry after his recovery.

More: Popular downtown Jacksonville lunch spot Olio closes after 11 years

Randeez Nutz Express

4985 Old St Augustine Road, #108

A year after debuting his brick-and-mortar restaurant, gourmet boiled peanut entrepreneur Randy Waters has closed Randeez Nutz Express. In a social media post announcing the closing on May 19, Waters noted that investors had purchased the lease to his restaurant. Offering his take on Cajun-Asian fusion cuisine, Waters opened the restaurant in May 2021 after staking his claim on elevating boiled peanuts from a humble roadside snack to gourmet fare from his popular Randeez Nutz trailer for five years.

More: Randeez Nutz Express comes to the end of the road as a brick-and-mortar restaurant

Sam Snead's Grill & Tavern

Jacksonville International Airport

Six months after reopening at Jacksonville International Airport, Sam Snead's Grill & Tavern closed in late August. The restaurant, which first opened 15 years replacing the Budweiser Brew House, was the only full-service restaurant located pre-security and available to all travelers and airport staff and visitors.

Changes at JIA: First opened 15 years ago, Sam Snead's Grill & Tavern closes to make way for airport expansion project

Simply Sara's

2902 Corinthian Ave.

After 12 years of “love, laughter, blood, sweat and many tears,” Simply Sara’s closed in July. Located in the heart of Ortega, the restaurant was known for its scratch-made authentic, Southern-style menu using closely-held, decades-old family recipes. Owners James and Sally Mangham first opened Simply Sara’s in 2011 in a small storefront in a nondescript retail strip in Murray Hill, offering takeout only. There, everything on the menu was made from scratch, including salad dressings, barbecue sauces, pimento cheese and tomato sauce. Within two years, the couple had moved to Ortega, where they were able to expand their concept, offering seating and adding menu items and staff.

'Hardest business ever to navigate': After 12 years of 'love, laughter, blood, sweat and many tears,' Simply's Sara's announces restaurant's closure

Sorrento Italian Restaurant

6943 St. Augustine Road

Opened in the mid-1980s by chef and owners Luciano and Joanne Russo, Sorrento was celebrated as offering a true slice of Italy, reminiscent to Russo's hometown of Naples. In a 1996 review, then Times-Union reviewer Tom Siegel wrote that "it is the quality and consistency of Russo's food that keep bringing the same people back year after year, month after month or again next week." After changing hands in recent years, Sorrento closed its doors for good in late August, ending its 35-year-run in the San Jose neighborhood.

'So grateful for the lovely friendships': After more than 35 years, Sorrento Italian Restaurant plans to close on Jacksonville's Southside

Sugarfire Smoke House

12959 Atlantic Blvd.

Open just a year, Sugarfire Smoke House closed, its owner citing supply chain shortages, staffing deficiencies and inflation. The restaurant, a franchised location of the popular St. Louis-based barbecue chain, struggled to find and retain employees even before it opened in the middle of the pandemic. "The past year has been a challenge for everyone, and we want to thank our staff for their hard work and dedication," owner Juli Dharna posted.

'Decision to close was not an easy one': Sugarfire Smoke House abruptly closes Jacksonville restaurant

Sweet By Holly

4624 Town Crossing Drive, No. 137

After 11 years at the St. Johns Town Center, gourmet cake and cupcake bakery Sweet by Holly closed in August unable to overcome challenges such as changing customer buying patterns and turn style-like staffing struggles rooted in the lingering aftermath of the COVID-19 pandemic. "The store simply ran out of time and money," Barry Wilder, who with his wife, celebrity chef Hollis Wilder, operated the Town Center bakery, told the Times-Union.

'Ran out of time and money': St. Johns Town Center gourmet bakery Sweet by Holly closes after 11 years

Willard's Bar-B-Q Junction

4610 San Juan Ave.

The Jacksonville barbecue institution known for its brisket, Carolina Hash and pulled pork closed permanently in late February. Owners Jimmy and Renee Willard, which opened the first Willard's in Callahan in 1991, opened or franchised more than 20 stores in Georgia and Northeast Florida. The San Juan Avenue location was the last to close. The couple cited the lingering effects of the COVID-19 pandemic as well as a recent series of health issues for the closure.

More: With fun and drive 'gone,' Willard's Bar-B-Q Junction closes after 30 years

Wing-It Jax

11018 Old St. Augustine Road

"We've had a good run. But you know I'm pushing 70 and with the times as uncertain as they are and my lease here is up. … It's time to move on," Dave and Charleen Morency told the Times-Union shortly before closing their restaurant in May. The couple had owned and operated the restaurant for nearly 25 of its 38-year history. In 1997, the Morencys bought Wing-It from a previous owner, who'd opened the business in 1984 at a nearby shopping center before relocating it to Mandarin Central shopping center in 1992.

'It's time to move on': After 38 years in Mandarin, popular mom-and-pop chicken wing spot Wing-It closes

Help us complete our list. If you know of a restaurant that has closed in 2022, email gmills@jacksonville.com.

This article originally appeared on Florida Times-Union: Jacksonville restaurants: A list of closings in 2022