Analysts See Softened Timelines For CRISPR Therapeutics' Sickle Cell Candidate In US
Barclays says that CRISPR Therapeutics AG's (NASDAQ: CRSP) Q2 FY22 earnings release was largely incremental, highlighting the progress of multiple clinical programs, including the goal of on-track regulatory submissions for CTX001 in SCD/BT by YE22 and CTA submission for VCTX211 (next generation) for Type 1 Diabetes (T1D) in 2H22.
Though investors are focused on BLA submission for CTX001, the analyst expects a high probability of approval even with some delay.
But Barclays has moved to the sidelines, given some questions on the durability of the allogeneic CAR-T programs and the lack of other major data catalysts in the next 12 months.
CRSP is downgraded to Equal Weight with a price target of $88.
RBC Capital notes that though SCD/BT filing remains on track for YE-22 in the EU, the Q2 release no longer cites US filing by YE-22, suggesting timing advantage vs. bluebird bio Inc (NASDAQ: BLUE) (still guiding 1Q23 filing) may have narrowed.
Overall, RBC struggles with the commercial case for SCD and read Pfizer Inc's (NYSE: PFE) buyout of Global Blood Therapeutics Inc (NASDAQ: GBT) as indirect evidence that gene therapy/editing is unlikely to disrupt the market in the foreseeable future materially.
RBC has lowered the price target from $85 to $78, reiterating the Sector Perform rating.
Price Action: CRSP shares are down 6.32% at $76.25 during the market session on the last check Tuesday.
Latest Ratings for CRSP
Date | Firm | Action | From | To |
---|---|---|---|---|
Feb 2022 | RBC Capital | Maintains | Sector Perform | |
Feb 2022 | SVB Leerink | Maintains | Outperform | |
Dec 2021 | Cowen & Co. | Initiates Coverage On | Market Perform |
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