Antibiotic reduces mothers’ risk of death during childbirth: UVA scientist
Infections among top five causes of maternal mortality worldwide.
CHARLOTTESVILLE — A single dose of the antibiotic azithromycin can help protect mothers from dangerous sepsis infections and death during vaginal childbirth, a sweeping new international study from a UVA Health scientist and his collaborators has found, according to a press release from University of Virginia Medical Center.
Azithromycin, also known as Z-Pak, has already been shown to benefit women delivering by cesarean section. But the new findings reveal that the common antibiotic reduces mortality for women delivering vaginally and cuts their risk of developing sepsis, a potentially fatal full-body infection, the study finds.
Infections, particularly sepsis, are responsible for 10% of maternal deaths shortly before, during and after childbirth, putting such infections in the top five causes of maternal mortality worldwide, the release said.
“A single dose of the antibiotic azithromycin decreased sepsis and death by half in women in labor,” said researcher Dr. William A. Petri Jr., of the University of Virginia School of Medicine’s Division of Infectious Diseases and International Health.
“The simplicity of this intervention should allow its institution around the globe to protect mothers during childbirth,” said Petri.
Safer childbirth
Petri is part of the Azithromycin Prophylaxis in Labor Use Study (A-PLUS) Trial Group, an international coalition of researchers that set out to determine if giving the antibiotic during childbirth would benefit either mothers or their children. More than 29,000 women in low- and middle-income countries volunteered to take part in the randomized trial; half were given azithromycin and half were given a harmless placebo, according to the study.
Among the 14,637 women who received the placebo, 2.4% developed sepsis or died within six weeks. That’s compared with only 1.6% of the 14,526 women who received azithromycin. The difference was clear enough that the researchers stopped the trial early, the release said.
The antibiotic did not provide similar benefits for the babies, the researchers found. However, they say that benefits for the mothers, combined with the lack of harmful side effects, makes azithromycin an important new tool for keeping moms safe before, during and after delivery. (The antibiotic is already recommended for caesarian births in the United States and elsewhere.)
UVA is one of seven universities participating in the Global Network for Women's and Children's Health. The network team at UVA includes Petri, Drs. Chris Chisholm (obstetrics/gynecology), Rob Sinkin (pediatrics), Chelsea Braun (medicine/infectious diseases) and Program Manager Lauren Swindell and, in Bangladesh, Drs. Rashidul Haque and Masum Billah of the icddr,b research center and Ruth Lennox of the LAMB Hospital.
Petri noted that the findings result from an important collaboration of scientists around the world working together to improve care for pregnant women and help them deliver their babies more safely.
“All of us engaged in the work of the network here in Charlottesville are enjoying the opportunity to collaborate across disciplines, each of us enriched by the perspectives of obstetricians, pediatricians and infectious-diseases specialists,” Petri said. “The network is open to all to propose new multi-site international studies in maternal and child health, and I hope that innovative ideas and ultimately clinical trials will originate here at UVA.”
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Findings published
The researchers have published their findings in the New England Journal of Medicine and was supported by The Eunice Kennedy Shriver National Institute of Child Health and Human Development and the Foundation for the National Institutes of Health through the Maternal, Newborn & Child Health Discovery & Tools initiative of the Bill and Melinda Gates Foundation.
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This article originally appeared on Staunton News Leader: Antibiotic reduces mothers’ risk of death during childbirth: UVA scientist
