Some women working in industries such as automotive plastics and food canning may face higher risk of breast cancer than those in other occupations, say Canadian researchers who are trying to fill gaps in what they call a neglected field.
Investigators in Windsor, Ont., compared 1,006 women diagnosed with breast cancer to 1,147 women of the same age without the disease in southwestern Ontario. They used interviews to investigate their occupational histories.
The researchers concluded that premenopausal breast cancer risk was doubled in the automotive plastic manufacturing and food canning industries, but experts questioned the credibility of deducing such as large effect from a small population.
The "exploratory" study "contributes to one of the neglected areas: occupational risk factors for breast cancers," Jim Brophy of the department of sociology, anthropology, and criminology at the University of Windsor and his co-authors conclude in Monday’s issue of the journal Environmental Health.
"The identification of several important associations in this mixed industrial and agricultural population highlights the importance of occupational studies in identifying and quantifying environmental risk factors and illustrates the value of taking detailed occupational histories of cancer patients."
Brophy said the evidence suggests the need to re-evaluate occupational exposure limits by regulators.
Women working in the automotive plastics industry described an injection moulding process that involves taking molten mixtures that exposed them to vapours and mists from plasticizers, pigments and flame retardants. These included compounds that have been identified as carcinogenic.
Brophy's team also found an elevated breast cancer risk among women working in farming, metal working like foundries, tool and dye shops. Those employed in casinos, bars and race tracks, where secondhand smoke exposure was common, were also at higher risk.
When the U.S. Institute of Medicine reviewed causes of breast cancer last year, it concluded the most consistent evidence of a link with increased breast cancer risk were from ionizing radiation, combination estrogen-progestin hormone therapy, and greater postmenopausal weight.
"But for many other factors, the evidence from human studies is more limited, contradictory, or absent," the U.S. researchers said.
For other factors, they said the evidence suggests a possible association, meaning no cause-and-effect relationship can be drawn. Exposure to secondhand smoke, nighttime shift work and exposure to chemicals such as benzene in some workplaces, were included in that category.
Paul Demers, head of the Occupational Cancer Research Centre in Toronto, has worked on trying to determine which Canadian industries have the highest exposure to carcinogens in the workplace.
A more reliable model takes a population and watches what happens over time.
"We're often looking backwards in time because we need answers now," Demers said.
Brophy's study could not identify exactly which chemicals the women were exposed to because many of the plants have since closed and records were not kept.
Not knowing the amount of exposure is one of the main limitations of the research, said Martin Yaffe, a senior scientist in imaging research at the Sunnybrook Research Institute, where he focuses on detecting breast cancer.
"Nevertheless, this work provides evidence for what may be an important cause of breast cancer — environmental exposure in the workplace," Yaffe said in email.
"In this case it may be possible, by knowing the carcinogenic potential of certain chemicals, to limit exposure to them by using alternative materials or by implementing appropriate safety measures, and in that way reduce the incidence of some types of breast cancers."