A video showed Cassie Laundrie and her husband fielding questions about her brother's case.
Laundrie and her husband, James Luycx, live in Lakewood Ranch, Florida.
She said she answered questions so that the protesters would leave her property.
Brian Laundrie's sister, Cassie, on Monday fielded questions from a small group of protesters on her lawn who she said were making her children upset.
"This is not what we want to be doing," Cassie Laundrie said. "This is not how we want the world to find out when we're angry and upset. But I can't have my kids be crying for three days in a row."
Cassie Laundrie and her husband, James Luycx, live in Lakewood Ranch, Florida, about 35 miles north of her parents' home in North Port, Fox 13 reported in September.
The video was taken by a man who claimed to know the Petito family, the NewsNation report said.
Cassie Laundrie said her parents' lawyer, Steven Bertolino, had advised them not to speak to anyone, including her. She added that they had not been in contact.
Bertolino has told CNN that the Laundries were at a campground on September 6 and 7 and left together.
Cassie Laundrie said she didn't know that Petito was missing when her family joined her parents and her brother at the campground on September 6. She added that she, Luycx, and their children stayed there from 2 to 8 p.m. on September 6 but left because the kids had school the next day.
"I'm in the boat where I'm getting ignored by my family and thrown under the bus by my family's lawyer," she said.
She added that she first learned Petito was missing on September 11, while she was on vacation in Orlando, when she received a call from a detective working with Petito's mother.
Cassie Laundrie said she had been unable to contact her brother since that day.
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