Buffalo Bills vs. Los Angeles Rams odds: NFL Week 1 point spread, money line, over/under

Jeremy Cluff, Arizona Republic
·2 min read
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The Buffalo Bills and Los Angeles Rams face off in the first game of the NFL season on Thursday, an NFL Week 1 contest.

The Bills are a 2.5-point favorite, according to Tipico Sportsbook.

Buffalo is -130 on the money line in the game, which will be played at SoFi Stadium in Los Angeles.

The Rams are +110.

The over/under for the game is set at 52.5 points.

NFL Week 1 odds:

The Los Angeles Rams are underdogs at home in their NFL Week 1 game against the Buffalo Bills.
The Los Angeles Rams are underdogs at home in their NFL Week 1 game against the Buffalo Bills.

The Bills went 11-6 in the regular season in 2021 and earned the No. 3 seed in the AFC playoffs, where they lost in the divisional round.

The Rams went 12-5 and were the No. 4 seed in the NFC playoffs. They won the Super Bowl.

NFL Week 1 picks, predictions:

These teams did not play last season.

The NFL Week 1 game is scheduled to kick off at 5:20 p.m. MST Thursday and can be seen on NBC.

NFL Week 1 schedule, TV information:

More: NFL power rankings before Week 1: Los Angeles Rams, Buffalo Bills open NFL season at top

More: Super Bowl 57 odds: Preseason betting odds for every NFL team to win 2022-2023 Super Bowl

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NFL's highest paid players in 2022:

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This article originally appeared on Arizona Republic: Buffalo Bills vs. Los Angeles Rams betting odds NFL Week 1 game