The rapper, real name Belcalis Almánzar, made history on Sunday night when she became the first female to win Best Rap Album for Invasion of Privacy .
But she was later taunted by cruel trolls who hit out at her win, as well as Ariana Grande who criticised the decision to award the rapper over her ex, the late Mac Miller.
Cardi B, 26, hit back by reminding fans she was pregnant at the time and her album went platinum before deleting her account.
“It’s not my style for people to put other people down, however I’ve been taking a lot of s***,” she said.
“I’m sick of this s***. I work hard for my motherf****** album. I remember last year when everyone was saying Cardi got snubbed but now this year it’s a problem?”
She then raged that her album went “two-times platinum in every chart that there was” and that she “worked her a** off for three months”.
She then told fans that she had been going home to “sleep for four days” while recording the album because she was pregnant at the time with her first child, Kulture.
On Sunday night, the artist dedicated her award to her seven-month-old daughter , who she shares with husband Offset.
In an emotional speech, Cardi B said: “When I found out [about the pregnancy], my album was not complete… we [had] to get this album done so I could shoot these videos while I’m still not showing. It was very long nights.
“You, husband, thank you. Nah, seriously, 'cause he was like, ‘you're going to do this album, girl. We're gonna have this baby, and we're gonna make this album’. And thank you so much, everybody.”