Both players were listed as questionable on Wednesday's injury report, but coach Kliff Kingsbury had left open the possibility that they could be ready for the game. Arizona backup running back Chase Edmonds is also inactive with a hamstring injury.
Arizona's other inactives are receiver Damiere Byrd, safety Charles Washington and defensive linemen Michael Dogbe and Zach Allen.
San Francisco's inactives are fullback Kyle Juszczyk, offensive tackle Mike McGlinchey, cornerback Ahkello Witherspoon, offensive tackle Joe Staley, receiver Marquise Goodwin, defensive tackle Jullian Taylor and quarterback C.J. Beathard.