Cedars-Sinai To Test Drug Remdesivir On Some Coronavirus Patients
LOS ANGELES, CA — Angelenos sickened with the coronavirus will have a chance to be part of the race for a cure for COVID-19 thanks Cedars-Sinai clinical trial. The hospital announced its participation in an international effort to test an experimental antiviral drug.
Cedars-Sinai will begin its first clinical trial on a patient this week, according to a statement released by the hospital. Dozens of hospitals worldwide will participate in the clinical trial by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. Doctors around the world will help evaluate the effects of the drug remdesivir in battling COVID-19. The drug was developed by the biopharmaceutical company Gilead Sciences Inc., based in Foster City, California. The drug Remdesivir has been touted as a promising treatment for the coronavirus, but it has yet to be thoroughly tested.
Cedars-Sinai plans to enroll up to 30 hospitalized COVID-19 patients for the trial. Some patients will get the drug while others will be administered a placebo.
Remdesivir is in a class of antiviral drugs designed to inhibit an enzyme that certain viruses, including the one that causes COVID-19, require to replicate themselves. The drug is not approved by the Food and Drug Administration (FDA) for marketing to the general public. At present, there are no specific FDA-approved therapeutics to treat people with COVID-19.
In animal studies, remdesivir has shown promise in counteracting other types of coronaviruses that caused two prior outbreaks of deadly respiratory diseases, known as SARS and MERS, according to Dr Victor Tapson, Cedars-Sinai site director for the NIH trial.
In a few anecdotal cases, significant improvement has been reported in COVID-19 patients who were administered remdesivir, said Tapson, who directs clinical research at the Women's Guild Lung Institute at Cedars-Sinai. But individual cases are not enough to prove the drug works, he said.
"We need randomized, controlled studies to verify that remdesivir is both safe and effective," Tapson said. "That is why this clinical trial is so important."
Of Cedars-Sinai's COVID-19 patients picked for the trial, one group will receive 200 milligrams of remdesivir administered intravenously on the first day, followed by a once-a-day maintenance dose of 100 milligrams for the duration of hospitalization, up to 10 days. The control group will receive injections of a placebo drug that appears identical to remdesivir but lacks the active ingredient.
At the end of the trial period, the investigators will compare outcomes of the treatment and control groups on clinical severity, hospitalization and mortality, and also evaluate the drug's safety.
In an NIH news release announcing the multicenter clinical trial, Dr. Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases and a member of the U.S. Coronavirus Task Force, stressed the trial's significance.
``We urgently need a safe and effective treatment for COVID-19. Although remdesivir has been administered to some patients with COVID-19, we do not have solid data to indicate it can improve clinical outcomes," Fauci said. ``A randomized, placebo-controlled trial is the gold standard for determining if an experimental treatment can benefit patients."
City News Service and Patch Staffer Paige Austin contributed to this report.
This article originally appeared on the Los Angeles Patch
