What is it?
A battle between two of the Premier League's big guns, both vying for a top-four finish. Ole Gunnar Solskjaer's side can put nine points between themselves and Chelsea if they win on Sunday.
When is it?
Sunday, February 28.
What time is kick-off?
What TV channel is it on?
Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HD.
What is the team news?
Thiago Silva is the only injury absentee for Chelsea, the Brazilian currently out with a muscle strain.
Paul Pogba will be the most high-profile omission for United as he continues his recovery from a thigh problem, while Edinson Cavani has been struggling with a niggle.
What are the latest standings?
What have we said about the clubs?
What are the odds?
Chelsea to win 5/4
Man Utd to win 9/4
What's our prediction?
After beating Atletico Madrid in midweek, confidence will be high as Chelsea welcome second-placed United to Stamford Bridge but Tuchel is well aware that the next five games could define their season.
After all the hard work to claw themselves back into the top-four race, having slipped to ninth under Tuchel's sacked predecessor Frank Lampard, Chelsea can ill afford any dip in form now.
Predicted score: Chelsea 2 Manchester United 1