Colts fans donate to Patricia Allen fund

Colts fans pay it forward after the Bills' win helps Indianapolis clinch a playoff spot.

Latest Stories

  • Biden showed his years of Senate experience by winning a filibuster fight without saying a word

    Analysis: Biden had nothing to gain and everything to lose from fighting a quixotic war over the filibuster just days into his presidency.

  • Pennsylvania teacher fights suspension over DC protest

    One day after the deadly insurrection in Washington, a Pennsylvania school district announced it was suspending a teacher who, the district asserted, “was involved in the electoral college protest that took place at the United States Capitol Building.” Three weeks later, Jason Moorehead is fighting to restore his reputation and resume teaching after he says the Allentown School District falsely accused him of being at the Capitol during the siege. The district says Moorehead’s social media posts about the events of Jan. 6, and not just his presence in Washington that day, are a focus of its probe.

  • Doctor with terminal cancer kills paediatrician in hostage siege a childrens clinic

    A doctor with terminal cancer killed a female paediatrician and then himself after taking hostages at a children's clinic in Austin, Texas. Dr Bharat Narumanchi held hostages in a five-hour siege before killing Dr Katherine Lindley Dodson. Narumanchi had applied for a volunteer position at the clinic a week ago and was declined. He later came back carrying a pistol, a shotgun and two duffel bags. Police spokesman Jeff Greenwalt said Narumanchi had recently been given "weeks to live" after a cancer diagnosis. He said: "The case as far as who did this is closed. We know who did it. And we know that there's no longer a threat to the public. But we really, really want to answer the question of why." Dr Lindley Dodson, 43, was beloved by patients and their families. Karen Vladeck, whose two children were among her patients, told the Austin American-Statesman: "You saw her at your worst when your kid was sick, and she just always had a smile on her face. "She made you feel like you were the only parent there, even though there was a line of kids waiting." During the siege a SWAT team used a megaphone to communicate with the armed doctor. A hostage negotiator shouted: "Your life is very important to me. And I know life is very important to you. "You don't deserve to go through this. For all you have done for others. That is why I want to help you work through this. You have saved a lot of lives." Police first sent in a robot and then officers went into the medical office where they found two bodies. They did not comment on how the two doctors died. A police spokesman said: "The SWAT situation has ended. Two subjects have been located and were pronounced deceased."

  • UK PM Johnson heads to Scotland amid fears of break up of UK

    Prime Minister Boris Johnson said the experience of the COVID-19 pandemic underlined the benefits of being part of the United Kingdom as he prepares to visit Scotland on Thursday to confront growing support for another independence referendum. The bonds holding together the United Kingdom have been severely strained over the last five years by Brexit, the government’s handling of the pandemic, and repeated calls by the Scottish National Party for a new referendum on independence. Ahead of his visit, Johnson said that Scotland as a part of the United Kingdom gained access to a coronavirus vaccine developed by the University of Oxford and they are being administered by their shared armed forces, who are creating 80 new vaccine centres in Scotland.

  • Biden news – live: Republican Party suffers ‘mass exodus’ as FBI thwarts plot against California governor

    Follow the latest updates

  • China warns Taiwan that 'independence means war’

    China toughened its language toward Taiwan on Thursday, warning after recent stepped-up military activities near the island that "independence means war" and that its armed forces were taking action to respond to provocation and foreign interference.

  • The Marines Want a Next-Gen Combat Utility Uniform. Here's What Could Change

    The move could save the service millions of dollars and provide wearers with better protection in the field.

  • Ruling brings kosher slaughterhouse new business, old fears

    In a small room lined with religious texts, a Jewish rabbi demonstrates how knives are sharpened and inspected before they are put to use slitting the throats of chickens, geese and other poultry at a kosher slaughterhouse in Hungary. A shochet, someone trained and certified to slaughter animals according to Jewish tradition, whets a knife on increasingly fine stones before drawing the blade across a fingernail to feel for any imperfections in the steel that might inhibit a smooth, clean cut and cause unnecessary pain. “One of the most important things in kosher is that the animal doesn’t suffer,” said Rabbi Jacob Werchow, who oversees production at Quality Poultry, a 3 1/2-year-old slaughterhouse that supplies nearly 40% of Europe's kosher poultry market and a large portion of the foie gras sold in Israel.

  • Man Charged With Hate Crimes After Kicking, Spewing Racial Slurs at Asian Woman in Portland

    A man in Portland, Oregon has been charged with bias crimes after allegedly kicking and racially attacking an Asian American woman last week. The incident, which left the victim with “some trouble walking,” occurred on a TriMet bus in the area of Southeast 52nd Avenue and Foster Road at 5:45 p.m. on Jan. 22. Eschright also allegedly used racial slurs during the encounter, mentioning the coronavirus in regards to the victim’s race and skin color.

  • Here Are The Brightest Decor Buys of the Season

    Let’s get loudOriginally Appeared on Architectural Digest

  • On his first day, Secretary of State Blinken commits to rebuilding U.S. diplomacy worldwide

    Antony Blinken began his first full day as U.S. secretary of state on Wednesday promising to repair ties with global partners and show the world that America can lead, while tackling climate change, the erosion of democracies and other complex issues. Greeted in the lobby and outside by a crowd of State Department employees limited by coronavirus measures, Blinken, who served as No. 2 at the State Department under former Democratic President Barack Obama, was greeted with applause. As challenges he cited the coronavirus pandemic, climate change, the global economy, threats to democracies, fights for racial justice, and the dangers to security and global stability posed by rivals and adversaries.

  • Biden’s new sign language interpreter runs a right-wing Facebook group and has been pictured in a MAGA hat

    One video featuring Heather Mewshaw is titled ‘Joe Biden is literally and legally not the President elect’

  • Army Testing 'Iron Man' Suit Component for Next-Gen Squad Weapon

    The aim control enhancer was once under consideration for the U.S. Special Operations Command's "Iron Man" suit program.

  • Fire captain accused of stealing vaccine turns himself in

    A Florida fire captain accused of stealing COVID-19 vaccines meant for first responders turned himself in Wednesday afternoon, sheriff's officials said. Polk County Fire Rescue Capt. Anthony Damiano, 55, faces a felony charge of falsifying an official record as a public servant and misdemeanor petit theft, according to a Polk County Sheriff's Office news release. Polk County Sheriff Grady Judd said at a news conference Tuesday that paramedic Joshua Colon, 31, was arrested Monday for covering up Damiano’s theft.

  • Government Support Needed to Drive Global Economic Recovery, IMF Says

    Global financial markets are receiving much-needed boosts heading into this year, thanks to earlier-than-anticipated approvals and distributions of multiple vaccines that are spurring hopes of recovery from the economic damage caused by the COVID-19 pandemic. But until inoculations become more widespread, policy support from governments will drive economic recovery worldwide, according to the 2021 Global Financial Stability Report Update released on Wednesday by the International Monetary Fund.

  • Former Obama speechwriter "preemptively frustrated" with Biden's unity efforts

    President Obama's former speechwriter says he's "preemptively frustrated" with President Biden's effort to find unity with Republicans.What they're saying: Cody Keenan told Axios that Biden's messaging team has "struck all the right chords," but at some point "they're gonna have to answer questions like, 'Why didn't you achieve unity?' when there's an entire political party that's already acting to stop it."Get smarter, faster with the news CEOs, entrepreneurs and top politicians read. Sign up for Axios Newsletters here.Keenan spent 14 years writing for Obama, including working alongside Biden for eight of those years. He acknowledged being embittered by his own experience, especially after Sen. Mitch McConnell pledged to make his former boss a one-term president. * "Until the Republican Party steps up and tells their own voters what's really happening with the truth, it's going to be elusive," Keenan said. "It's not up to (President Biden) alone to deliver. He can't."Keenan helped Obama with the first volume of his memoir, "A Promised Land." He stopped working with the former president on New Year's Eve and has taken a full-time role at Fenway Strategies. The firm is run by another ex-Obama speechwriter — Jon Favreau — and presidential aide, Tommy Vietor. * "It just seemed like a natural spot after the book and the elections and, you know, [Obama] is not going to do a ton, especially with Biden in office," Keenan said.Keenan is also writing a book, titled "Grace," about the 10 days from the 2015 shooting at a historic Black church in Charleston, South Carolina, to the eulogy Obama delivered for Rev. Clementa Pinckney. * Obama ended by singing "Amazing Grace." * The title also nods to Keenan's newborn daughter, named Grace.Support safe, smart, sane journalism. Sign up for Axios Newsletters here.

  • Jill Biden spent her first week as First Lady reshaping the role. Melania Trump spent hers isolated in a tower

    New first lady signals she will be an active and constant presence in the White House - drawing stark contrasts to her predecessor

  • Why it takes 2 shots to make mRNA vaccines do their antibody-creating best – and what the data shows on delaying the booster dose

    After a second dose of the COVID-19 mRNA vaccine, a swarm of antibodies attacks the virus. Kateryna Kon/Science Photo Library via Getty ImagesWith the U.S. facing vaccination delays because of worker shortages and distribution problems, federal health officials now say it’s OK to push back the second dose of the two-part vaccine by as much as six weeks. As an infectious disease doctor, I’ve been fielding a lot of questions from my patients as well as my friends and family about whether the COVID-19 vaccine will still work if people are late receiving their second dose. Why you need two doses 3-4 weeks apart Two doses, separated by three to four weeks, is the tried-and-true approach to generate an effective immune response through vaccination, not just for COVID but for hepatitis A and B and other diseases as well. The first dose primes the immune system and introduces the body to the germ of interest. This allows the immune system to prepare its defense. The second dose, or booster, provides the opportunity for the immune system to ramp up the quality and quantity of the antibodies used to fight the virus. In the case of the Pfizer and Moderna COVID-19 vaccines, the second dose increases the protection afforded by the vaccine from 60% to approximately 95%. Why the CDC decided receiving the second dose within 42 days is OK In the clinical trial, the second dose of the Pfizer vaccine was administered as early as day 19 and as late as day 42 to 93% of the subjects. Since protection was approximately 95% for everyone who was vaccinated within this time “window,” there is little reason not to allow some flexibility in the timing of the second dose 2. As more vaccine becomes available, the timing of the second dose should be close to four weeks for the Pfizer and Moderna vaccines. But the good news is that even while supplies remain limited, the science suggests that there’s nothing bad about getting a second dose as late as 42 days after the first. What the immune system does between the first and second dose The biology through which the mRNA vaccines induce their protection from COVID-19 is fundamentally different from that with other vaccines. Pfizer and Moderna vaccines use messenger RNA that encodes the spike glycoprotein. Upon injection of the vaccine, the mRNA enters into immune cells called dendritic cells. The dendritic cells use the instructions written in the mRNA to synthesize the hallmark spike glycoprotein, which characterizes the SARS-CoV-2 virus that causes COVID-19. These immune cells then show the spike glycoprotein to B-cells, which then make anti-spike antibodies. Dendritic cells recognize viruses and present information about the spike protein to T-cells. T-cells provide information about the viral spike protein to B-cells, which are transformed to memory B-cells that store information about the virus. When this memory B-cell is activated with an infection or the second dose of the vaccine, this causes some of the B-cells to change into plasma B-cells that secrete protective antibodies that fight the virus. Kateryna Kon/Science Photo Library via Getty Images The mRNA vaccines are uniquely capable of inducing a special kind of immune cell – called a T-follicular helper cell – to help B-cells produce antibodies. The T-cells do this through direct contact with the B-cells and by sending chemical signals that tell the B-cells to produce antibodies. It is this help in antibody production that makes these vaccines so effective. But not all B-cells are the same. There are two kinds that make anti-spike antibodies: long-lived plasma cells and memory B-cells. The long-lived plasma cells, as their name implies, live in the bone marrow for years after vaccination, continuously churning out antibody – in this case anti-spike antibody. These long-lived B-cells do not need to be boosted. The memory B-cells, on the other hand, live in a state akin to hibernation. They do not produce antibodies until stimulated by a booster of the vaccine, or are exposed to infection with the coronavirus that causes COVID-19. That is the reason we need that second dose. Together these two types of B-cells provide a constant level of protection. What happens if you don’t get the Pfizer or Moderna second dose on time? With current vaccine shortages, and problems with setting up the infrastructure to vaccinate millions of people, many physicians are concerned that the second dose of vaccine won’t be delivered in the prescribed three-to-four-week window. That booster shot is necessary for the T-cells to stimulate the memory B-cells to produce massive quantities of antibodies. If the booster isn’t given within the appropriate window, lower quantities of antibodies will be produced that may not provide as powerful protection from the virus. [Deep knowledge, daily. Sign up for The Conversation’s newsletter.]This article is republished from The Conversation, a nonprofit news site dedicated to sharing ideas from academic experts. It was written by: William Petri, University of Virginia. Read more:How mRNA vaccines from Pfizer and Moderna work, why they’re a breakthrough and why they need to be kept so coldCOVID-19 vaccines were developed in record time – but are these game-changers safe? William Petri receives research funding from the NIH, the Bill & Melinda Gates Foundation and Regeneron, Inc.

  • Driver accused in Oregon road rampage pleads not guilty

    A motorist accused of hitting pedestrians, bicyclists and killing a 77-year-old woman Monday in Portland, Oregon, has pleaded not guilty to murder and has given detectives bizarre explanations about the incident, according to court documents. Paul Rivas, 64, through a court-appointed lawyer, also pleaded not guilty Wednesday to six counts of second-degree assault, six counts of failure to perform the duties of a driver after causing injuries, and one count of failure to perform the duties of a driver resulting in a death. Prosecutor Sean P. Hughey wrote in a probable cause affidavit that Rivas initially told investigators his Honda Element was having brake problems and that he was searching for an auto repair shop.

  • 47 Best Housewarming Gifts to Celebrate a New Home

    Everything they need to put the horrors of moving behind themOriginally Appeared on Architectural Digest