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Bryant stepped hard on first and tumbled to the ground in the third inning. The 2016 NL MVP then had to be helped off the field.
The team says X-rays taken at the ballpark were negative.
Bryant was bothered by right knee soreness for part of the summer. He is batting .282 with 31 homers and 77 RBIs.
Ian Happ replaced Bryant at third base on Sunday.