Don't skip the bug spray: Alpha-gal cases are climbing

Nov. 1—STILLWATER — Oklahoma State University Extension specialists say residents should remain diligent in preventing tick bites as the alpha-gal allergy emerges as a serious health in Oklahoma and the southeastern U.S.

Tick bites are rare during the cooler months, but the pests are considered a year-round threat in states with mild winter temperatures.

12 years of mysterious illness

Sand Springs resident Stephanie McAllister developed a mysterious cough in 2008 that baffled medical specialists. She coughed constantly, but every X-ray was clear and every test declared normal. The pulmonologist she visited mentioned a chronic cough is usually an indicator of some kind of allergy, but no diagnosis was determined. Doctors suggested several serious medical ailments as the probable cause, including bulimia or anxiety. McAllister felt like she was going crazy, but deep down she knew none of these were the problem.

"I started having brain fogginess and joint pain in my arms and legs, but all of the tests ran for arthritis came back normal," she said.

In 2019, while hiking around Keystone Lake near her home, McAllister was bit by a tick and began vomiting five or six times a day. Again, every test doctors administered came back normal.

"I started Googling symptoms and reading articles," she said. "I went to three different doctors and asked them to do an alpha-gal test, and they all said it was too rare, that there was no way I had it."

Frustrated with 12 exhausting years of unexplained illness, McAllister started eating a vegan diet. Her symptoms disappeared, and she suspected alpha-gal was the culprit. In 2020, she found an urgent care that reluctantly ran the simple alpha-gal blood test, and the result was positive.

"It was a relief to know," McAllister said. "I had it for so long, and I was just thankful I knew what to do to feel better."

Today, she consumes chicken and seafood, but her avoidance of red meat is more complicated than it sounds.

"I have to be really careful with anything that's processed because beef and pork aren't listed on allergy labels," she said. "Any box, can or bag that lists natural flavors as an ingredient could have beef or pork in it. I know if I eat it, I'm going to feel terrible for the next three days."

High risk in northeast Oklahoma

A report from the Centers for Disease Control in July 2023 illustrates the geographic distribution of suspected alpha-gal syndrome cases from 2017 to 2022. The northeast and central regions of Oklahoma report some of the highest rates of alpha-gal in the country.

"Mammals have the alpha-gal compound, but humans don't," said Janice Hermann, OSU Extension nutrition specialist. "When a tick feeds on a mammal and bites a human, it can cause the human to have an allergic reaction to alpha-gal."

Meat from beef, pork and venison contain the compound and can enact a severe allergic reaction. In some cases, even milk, gelatin or beef broth can heighten alpha-gal syndrome.

Hermann explained the allergy is difficult to identify because of its delayed reaction.

"Food allergy symptoms usually occur rapidly whereas alpha-gal syndrome may not show symptoms until 2 to 6 hours after consuming the product," Hermann said. A lot of times, people don't associate it with the fact they consumed meat."

The CDC lists the following symptoms of an alpha-gal allergic reaction:

—Hives, itchy skin or rashes

—Nausea or vomiting

—Heartburn or indigestion

—Diarrhea

—Cough, shortness of breath or difficulty breathing

—Drop in blood pressure

—Swelling of the lips, throat, tongue or eyelids

—Dizziness or faintness

—Severe stomach pain

Health issues had consumed Stillwater resident Ryane Draper's life for two years,

"I had extreme fatigue. I felt like someone was drugging me every day," Draper said. "I had terrible joint inflammation, constant digestive issues, stomach pains bloating, and I was also reactive to dairy."

After a significant reaction to a meal with pork, she visited a doctor who had diagnosed a previous patient with alpha-gal. The doctor ran the same blood test on Draper, confirming the allergy in 2020.

"I'm able to consume a little bit of milk and ice cream here and there, but if I eat too much, I can feel it almost immediately," Draper said. "If cutting out certain foods works, that's what I'm going to do."

For those who have alpha-gal syndrome, some can trace the allergy to a specific tick bite. Others were never aware of a tick on their body. Bruce Noden, associate professor of medical/veterinary entomology in the OSU Department of Entomology and Plant Pathology, has personal experience with the health condition. His son was diagnosed shortly after high school.

"He got into a bunch of seed ticks out at Lake McMurtry and wound up in the hospital with anaphylaxis," Noden said. "He calls me at 11:30 at night and says, 'Dad, I can't breathe.'"

His son is one of the lucky alpha-gal victims whose symptoms eventually faded.

"We ate fish and chicken for two years in our house, and when he tried to reintroduce red meat, he came out of it," Noden said.