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Now a favourite fighting out of Dallas, Spence Jr escaped death in a serious car crash last year, but has chosen not to accept a soft touch on his return to boxing, with the WBC and IBF titles up for grabs.
The 31-year-old will look to prove he has shaken off any lingering effects from the accident, with a potential super fight with Manny Pacquiao or Terence Crawford up next, with the latter defeating Kell Brook last time out before agitating for his Top Rank exit to clinch the career-defining fights.
The 147-pound division is heating up with Garcia victorious last time out against Ivan Redkach and now looking to prove his worth at the elite level once again after falling short against Shawn Porter in 2018 for the WBC crown.
Porter would go on to defend the green and gold against Yordenis Ugas before relinquishing the belt to Spence Jr in September last year.
Here is everything we know about the fight and how you can watch it:
When and where is the fight?
The fight is on Saturday, 5 December in Arlington, Texas at the Dallas Cowboys’ home, AT&T Stadium.
It will see around 11,000 fans in attendance with the Cowboys already showcasing their ability to welcome socially-distanced spectators during the NFL season.
The fight will start on 6 December in the UK, with ring walks expected after 4am and the fight to start 15-20 minutes following that.
What TV channel is it on and is there a live stream?
Errol Spence Jr vs Danny Garcia will be broadcast in the UK on Premier Sports.
The service is available through their monthly payment option of £9.99, which also includes Guinness PRO14 rugby, La Liga and Serie A - sign up to purchase the big fight here.
The action can then be streamed from any mobile or tablet device or cast straight onto a smart TV with the official Premier Sports app.
Spence vs Garcia full card
Sebastian Fundora vs Jorge Cota
Josesito Lopez vs Francisco Santana
Julio Ceja vs Eduardo Ramirez
Errol Spence Jr: 1 / 3
Errol Spence Jr by KO or TKO: 11 / 4
Errol Spence Jr by decision: 8/11
Danny Garcia: 9/4
Danny Garcia by KO or TKO: 9/1
Danny Garcia by decision: 9/2