Former 49ers No. 1 overall pick QB Alex Smith retires

Alex Smith is calling it a career. The former 2005 San Francisco 49ers first-round pick announced on his Instagram account Monday that he will retire from the NFL. Alex Smith is calling it a career. The former 2005 San Francisco 49ers first-round pick announced on his Instagram account Monday that he will retire from the NFL. Alex Smith is calling it a career. The former 2005 San Francisco 49ers first-round pick announced on his Instagram account Monday that he will retire from the NFL. To everyone out there, whether you’re a part of Niner Nation, the Chiefs Kingdom, or the Burgundy and Gold, I thank you.

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