The crash happened at 51st Street and 7th Avenue, near Times Square.
They are currently calling the damage a 2-alarm fire, and have deployed over 100 emergency workers to the scene.
In a press conference in the area, New York governor Andrew Cuomo said "The only indication was a helicopter had to do an emergency, or a hard landing, or crashed onto the rooftop of a building, causing a fire. There's no indication of anything more than that."
Mr Cuomo also said: "If you're a New Yorker, you have a level of PTSD from 9/11. So as soon as you hear, an aircraft hit a building, I think my mind goes where every New Yorker goes."
Two city officials said there was one person on board, who was reported to be injured, according to the New York Times.
Kathleen Bergen, spokesperson for the Federal Aviation Administration, said they are gathering information on today's crash landing in Manhattan.
Donald Trump has been briefed on the helicopter crash is monitoring the situation, according to White House spokesperson Hogan Gidley.
The press secretary for New York City mayor Bill de Blasio says he has received preliminary briefing on the crash and is on his way to the scene.