Jennifer Aniston gives advice on smoking weed for the first time during Howard Stern interview

Howard Stern has temporarily set up shop in Los Angeles, and his crew is certainly taking full advantage of their time on the West Coast.

During his interview with Jennifer Aniston, Stern called over one of his producers, 39-year-old J.D. Harmeyer, who'd agreed to try marijuana for the very first time in his life. Aniston, a Los Angeles native, was floored.

"You're going to smoke weed for the first time?" Aniston, incredulous, asked. "You really haven't? And you grew up here?" 

Harmeyer clarified, "Oh, no. I'm from Ohio."

After Stern pressed her to share some wisdom, she replied, "Just pace yourself," adding, "Are you smoking it or are you eating it? Did you say Jimmy is going to help you?" (Jimmy Kimmel had offered his own advice during his earlier interview.)

Although she was short on specifics, Aniston simply advised, "It's either going to be the worst day of your life or the best day of your life. Don't worry, you'll live."

Stern indicated that his producer's marijuana experience will be documented on the show, telling Aniston that Seth Rogen and Snoop Dogg will serve as his guides.

"Oh, well, there's your company. You couldn't have better company," she said.

During another portion of the interview, Aniston told Stern that she and all of her "Friends" co-stars had dinner together over the weekend. "We all miss it every day," she said. "I would be nothing without it."