By Natalie Grover (Reuters) - Israel-based drugmaker Kamada Ltd said its experimental drug failed in a key trial to treat an inherited condition that raises the risk of lung and liver disease. Kamada's stock plunged almost 35 percent in heavy trade on the Nasdaq on Friday. "I think its clear to say they wont be able to file (for U.S. approval) off of these results, unless there's something magical they're planning to release in the third quarter," H.C. Wainwright & Co analyst Andrew Fein said. The biotechnology company said on Friday that it planned to release detailed results of the study in the third quarter. Fein added that he would keep expectations "modest" on the possibility of European approval, saying the company needed to conduct another study with a different trial design. The 50-week trial was testing the inhaled drug, AAT, against a placebo in 168 patients with a type of protein deficiency. Early data showed that the treatment was not more effective than the placebo. While Kamada's intravenous version of the drug, Glassia, is being sold by Baxter Inc in the United States, the inhalable version could offer a more targeted form of therapy, delivering the drug directly to the lungs. The treatment is delivered using an eFlow Nebulizer System, developed by Kamada's German partner, PARI Pharma. Glassia, Kamada's sole product on the market, is also in use in Israel, Brazil and Russia. The common hereditary disorder, called Alpha-1 Antitrypsin deficiency, is characterized by low levels of alpha-1 antitrypsin - a protein released by white blood cells that digests bacteria and other foreign objects, primarily in the lungs. The deficiency, often misdiagnosed as asthma or bronchitis, predisposes individuals to several conditions, including lung and liver diseases and sometimes panniculitis — a skin condition. Fein estimated that the European market for the condition could be worth $100 million, and at least three times as much in the United States. The disease affects 1 in 2,500 people in the United States, according to the Alpha-1 Association. The company is also evaluating the treatment for use in cystic fibrosis, bronchiectasis and diabetes. Kamada's shares were trading down 34 percent at $9.11 in late morning trade. (Reporting by Natalie Grover in Bangalore; Editing by Simon Jennings)
- The Daily Beast
Frederick M. Brown/Daily Mail.com via APA traveling Texas nurse is facing multiple murder charges after running a red light and crashing into traffic while allegedly driving 90 mph in Windsor Hills, California.Los Angeles County District Attorney George Gascón announced on Monday that Nicole Linton has been charged with six counts of murder and five counts of gross vehicular manslaughter for the multi-car crash, which left six people dead and Linton facing a 90-year prison sentence if convicted
Feds likely obtained 'pulverizing' amount of evidence ahead of searching Trump's Mar-a-Lago home, legal experts say
During an extensive review process, Donald Trump's FBI appointee Christopher Wray most likely had to approve the search warrant.
On Aug. 8, the FBI executed a search warrant for Donald Trump’s Mar-a-Lago resort in Palm Beach, FL and needless to say, the former president was anything but pleased.
- Myrtle Beach Sun News
Josh Wilson, 40, of West Virginia was killed during his weekend vacation to Myrtle Beach with his wife and kids.
- Rolling Stone
Conservatives are doing what they do best in the wake of the FBI searching Donald Trump's Palm Beach estate: playing the victim
- Business Insider
Rudy Giuliani says he can't make the trip to testify before a Georgia grand jury. But Fulton County prosecutors say they have receipts showing he's got no problem traveling.
Rudy Giuliani pointed to an unspecified medical condition to request a delay of his August 9 appearance before a grand jury in Fulton County, Georgia.
Lawyers received instructions to secure Trump's document room months before the FBI search at Mar-a-Lago: report
After federal investigators met with Trump's attorneys, aides added a padlock to the room where documents were stored.
- Country Living
Actress Halle Berry, 54, showed off her toned back and legs in a new swimsuit photo. The actress is known for her hardcore workouts and following a keto diet.
- The Root
Another day, another Karen. A video has been circulating social media of a white woman calling the police to report a Black man for standing outside his house, according to The Seattle Times. Yes, just standing. The woman accused the man of being a burglar but insisted race had “nothing to do” with her choice to profile him.
Either that or he's listening to a lot of Bo Burnham.
Newton-John had been open about her breast cancer journey since she was first diagnosed in 1992 at the age of 43.
Olympic gymnastics champ Suni Lee flipped head-over-heels as she threw the first pitch at the Minnesota Twins and Toronto Blue Jays game.
- Yahoo TV
Lara Trump incorrectly claims that Donald Trump had 'every authority' to take documents from White House
In taking official presidential documents when he left the White House, former President Trump violated the Presidential Records Act.
- Giants Wire
Shortly after an aggressive run by Saquon Barkley during practice, New York Giants players and coaches erupted into a massive brawl.
A teenage girl has gone viral after sharing on the social media website Reddit that she is evicting her family, including her pregnant stepsister.
- E! News
Three months after announcing she is expecting her first child with boyfriend Sid Wilson, Kelly Osbourne showed off her baby bump during a night out with her parents in London.
- NBC Sports
Durant pushed for Nash to be the head coach.
- Women's Health
Gabrielle Union is strong and sculpted in a nude photo she posted to Instagram. The actress, 49, has been embracing her strength and mental health goals lately.
Journalist and former Olympian Matthew Syed would've never expected his 8-year-old son to strike up a random conversation with the Duchess of...
- E! News
No Sunday scaries over here! Priyanka Chopra and Nick Jonas finished off their weekend by enjoying brunch, time in the pool and a game night. See their recent family photo with daughter Malti.