The nurse, Talisa Hardin, was among several frontline workers who received phone calls from the vice president-elect and her husband Doug Emhhoff this Thanksgiving.
"You know, I just wanted to see you to say happy Thanksgiving and just for everything you do every day," Ms Harris said on the phone call.
"I've been reading about you and just all that you do in service of so many people,” she added.
The vice president-elect said she and her husband wanted to thank those who had worked to battle the coronavirus in hospitals across the country, in a Twitter post.
“Earlier today Douglas Emhoff and I called Talisa, a registered nurse in Chicago,” wrote Ms Harris, “and a few of our nation’s frontline workers to thank them for everything they have done in the fight against COVID-19.”
“We won’t be able to get through this without them,” she added.
Americans marked the annual holiday on Thursday as some 90,000 people were hospitalised with the virus. More than 263,000 Americans have died, while some 12.9 million Americans have contracted the virus since the pandemic began, according to John Hopkins university data.
Speaking ahead of the Thanksgiving holiday, president-elect Biden called on Americans to pull together, while thanking those who have been on the frontline of the crisis.
“We're at war with the virus, not one another,“ said Mr Biden. “We have to slow the growth of this virus. We owe it to the doctors and the nurses and the frontline workers ... We owe it to our fellow citizens."