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Kansas City Chiefs vs. Arizona Cardinals odds: NFL Week 1 point spread, money line, over/under

The Kansas City Chiefs and Arizona Cardinals face off in an NFL Week 1 game on Sunday, Sept. 11

The Chiefs are a 4.5-point favorite, according to Tipico Sportsbook.

Kansas City is -205 on the money line in the game, which will be played at State Farm Stadium in Arizona.

The Cardinals are +165.

The over/under for the game is set at 53.5 points.

NFL Week 1 odds:

Patrick Mahomes and the Kansas City Chiefs are favored against the Arizona Cardinals in their NFL Week 1 game.
Patrick Mahomes and the Kansas City Chiefs are favored against the Arizona Cardinals in their NFL Week 1 game.

The Chiefs went 12-5 in the 2021 season and lost in the AFC Championship Game.

The Cardinals went 11-6 last season and lost in the NFC Wild Card Round.

NFL Week 1 picks, predictions:

The teams did not play each other last season.

The NFL Week 1 game is scheduled to kick off at 1:25 p.m. MST Sunday and can be seen on CBS.

NFL Week 1 schedule, TV information:

More: NFL power rankings before Week 1: Los Angeles Rams, Buffalo Bills open NFL season at top

More: Super Bowl 57 odds: Preseason betting odds for every NFL team to win 2022-2023 Super Bowl

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NFL's highest paid players in 2022:

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Kansas City Chiefs vs. Arizona Cardinals betting odds NFL Week 1 game