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The model and actor, 41, told the Daily Mail that she was content at a curvy size 12, and in a happy relationship with her partner of six years Jeremy Parisi.
Admitting that a lot of her experiences in her 30s had made her "really unhappy", she said that many of her relationships had been with people she knew she didn't want to have children with or marry.
Brook's past partners include actors Jason Statham and Billy Zane, rugby players Danny Cipriani and Thom Evans, and former Royal Marine David McIntosh, all of who apart from Cipriani she was engaged to.
She said: "It's more difficult to have children after 40, I know that. But if it's something you don't really want to do, it's OK. I didn't really want to have children. I didn't want to get married and that's OK. It's OK to say that now."
Brook added that the things that made her happy now - her boyfriend, home, job and travelling - were not the things she had thought she would be aiming for in her 30s.
Sharing that her weight had yo-yoed during lockdown thanks to buying a pizza oven and ice-cream maker, Brook said that she was happy being curvy and wasn't aiming for thinness now.
The star said: "I've never hated who I am, and I do embrace my bigger size. I don't want to be like I was in my 20s - I couldn't if I tried, my metabolism has slowed right down - but I'm also aware things can get out of hand and I do have that body type where I can gain weight quickly."
While Brook says she loves her job now, she has in the past shared her frustration that big stars in Hollywood hadn't spoken out against Harvey Weinstein sexually harassing female stars sooner, although she now says she understands why they felt they couldn't.
Read more: Kelly Brook 'lives a nice, selfish life'
Brook said of her own experiences working in the film industry and coming into contact with Weinstein: "I wasn't a success in Hollywood was I? Why was that? OK, I'm not a great actress, but it doesn't matter, let's be honest. I'm sure if I'd played the game I'd have been in a few more movies."
Watch: Kelly Brook - I don't have the instinct for marriage or kids