LIVE: Matt Ryan's huge day leads Colts to thrilling win over Jaguars

The Indianapolis Colts meet the Jacksonville Jaguars for the second time this season in NFL Week 6 action at Lucas Oil Stadium.

The Colts (2-2-1) are missing some key players due to injury, but they had extra prep time after beating the Denver Broncos 12-9 in overtime on Thursday night of Week 5. The Jaguars (2-3) have lost two games in a row, cooling off after a start that included a 24-0 Week 2 win over the Colts.

Joel A. Erickson, Nate Atkins, Akeem Glaspie, Matthew VanTryon and Gregg Doyel will have updates and analysis throughout. We'll have highlights and score updates here, so please remember to refresh.

Watch: Colts don't tie the Jaguars on 2-point conversion attempt to Michael Pittman Jr.

Injury:Colts punt returner Keke Coutee being evaluated for head injury after scary hit

Final: Colts 34, Jaguars 27

Matt Ryan has his busiest day as a Colt, going 42-of-58 for 389 and 3 touchdowns. That's Ryan's most attempts in his career.

Michael Pittman Jr. has 13 catches for 134 yards, and Deon Jackson has 10 for 79. Jackson also rushes for 42 yards, but he leaves late with a quad injury.

The Colts have their highest-scoring game of the season and don't allow Ryan to be sacked.

Trevor Lawrence uses his arm and legs. He completes 20-of-22 passes for 160 yards, and he rushes 6 times for 23 yards and 2 touchdowns. Travis Etienne has 10 carries for 86 yards, and 2 catches for 20 yards. Jacksonville rushes for 243 yards and doesn't allow a 2nd-half sack of Lawrence, who went down 4 times in the first half.

The Colts (3-2-1) visit the Tennessee Titans (3-2), who will be coming off a bye, in Week 7.

:17 left 4Q: Colts score in closing seconds

Matt Ryan hits Alec Pierce for 32 yards down the right sideline, Pierce's first career touchdown. Philip Lindsay runs in the 2-point conversion Colts 34, Jaguars 27

Ryan hits Pittman for 15 yards to convert a 3rd-down play. The Colts are at the Jaguars 29.

2:00 left 4Q: Colts drive

Matt Ryan hits Michael Pittman Jr. for a 1st down at the Colts 44.

The Colts start from their 34 after Isaiah Rodgers' kickoff return from the goal line.

2:44 left 4Q: Jaguars use clock, take the lead

Trevor Lawrence hits Christian Kirk from 3 yards, capping a drive of 18 plays and 10:03. The 2-point try is incomplete. Those are the first points the Colts have allowed in the 4th quarter this season. Jaguars 27, Colts 26

Jacksonville has converts on 4th down at the Colts 40 with 5:30 remaining. The Jaguars also converted twice on 3rd down after the penalty.

Stephon Gilmore commits pass interference on Zay Jones on a 3rd-down pass.

12:47 left 4Q: Colts take the lead

Matt Ryan hits Jelani Woods for a 10-yard score, the rookie's 3rd this season. The Jaguars want offensive pass interference on the play. This is the Colts' highest-scoring game of the season and they have 3 red zone touchdowns today. Colts 26, Jaguars 21

For the second time, Shaquille Griffin interferes with Alec Pierce. Colts ball at the Jaguars 10.

Starting 4th quarter: Colts are in Jaguars territory

Matt Ryan hits Parris Campbell for a 1st down at the Jacksonville 48.

Ryan has 292 passing yards. Jacksonville has 204 rushing yards.

Fun fact: Colts have allowed 0 4th-quarter points this season.

1:09 left 3Q: Colts stop the Jaguars on downs

E.J. Speed gets Travis Etienne for a loss on 4th-and-1 from the Colts 32. Indianapolis takes over at its 34. The Jaguars are 4-of-12 on 4th-down conversions.

5:44 left 3Q: Colts drive for touchdown

Deon Jackson runs in from 3 yards, the Colts' 2nd rushing touchdown of the season. Michael Pittman Jr. can't quite hold on for the 2-point conversion. That's the Colts' 1st 2-point try this season. Jaguars 21, Colts 19

Matt Ryan passes Dan Marino (61,361) for 7th in NFL career passing yards.

Travon Walker roughs Ryan on a 3rd-down incompletion. The 1st overall NFL Draft pick in 2022 predicted a big day against the Colts QB, calling Ryan a "sitting duck."

10:55 left 3Q: Jaguars open second half with scoring drive

Trevor Lawrence has his second rushing touchdown of the day, from 2 yards. Jaguars 21, Colts 13

Defensive holding on a 3rd-down incompletion extends the drive. First play from scrimmage of the second half: Travis Etienne rushes for 27 yards. He has 5 carries for 75 yards.

Halftime: Jaguars 14, Colts 13

The Colts have not led at halftime for 8 straight games, dating to last season.

Matt Ryan has been busy, hitting on 26-of-37 passes for 231 yards and a touchdown to Parris Campbell. Michael Pittman Jr. has 8 catches for 81 yards and Deon Jackson 8 for 76 yards as they largely ignore the run.

The quick passing game has led to 0 sacks allowed. The Colts led the league with 21 allowed over the first 5 weeks.

Jacksonville has rushed for 150 yards and 2 touchdowns, ripping through the league's 4th-best rushing defense.

The Colts have sacked Trevor Lawrence 4 times after not getting to him in Week 2. He has completed 7-of-8 passes for 45 yards.

:21 left 2Q: Colts edge closer Jaguars

Chase McLaughlin hits from 42 yards. Jaguars 14, Colts 13

1:31 left 2Q: Colts get another chance

The Colts have 4 sacks of Trevor Lawrence and they get the ball at their 39 after a punt. Keke Coutee returns the punt 19 yards but is hurt on the play. He heads to the locker room.

2:06 left 2Q: Colts score a touchdown

Matt Ryan hits Parris Campbell, who reaches the ball to touch the pylon and notch the 4-yard touchdown. The Colts went 117 minutes, 48 seconds of game time between touchdowns. Jaguars 14, Colts 10

Dennis Kelly, who has been rotating with Bernhard Raimann at left tackle, gets the a holding call, pushing the ball back to the 18.

A pass interference call by Shaquille Griffin puts the ball at the 8-yard line. Ryan Kelly recovers after Kylen Granson fumbles on a screen pass. A Matt Ryan-to-Deon Jackson screen pass gets the Colts back into the red zone.

6:34 left 2Q: Colts sack Trevor Lawrence to force a punt

Tyquan Lewis gets his first of the season on 3rd-and-2. Colts get it at their 46 after a strange play. Isaiah Rodgers Sr. picks it up on the bounce and returns it 19 yards.

8:43 left 2Q: Colts stall after reaching Jaguars territory

The drive ends with a Matt Ryan intentional grounding call. The Colts punt and Jacksonville takes over at its 11.

11:27 left 2Q: Jaguars run by Colts for a touchdown

Jamycal Hasty goes untouched for 61 yards on 3rd-and-1. It's his second carry of the season. The Jaguars have 145 rushing yards. The Colts average allowing 96 rushing yards per game. Jaguars 14, Colts 3

13:56 left 2Q: Colts get on the board

Chase McLaughlin hits from 28 yards after the drive stalls at 10-yard line. Three Matt Ryan passes fall incomplete after they reach the 10. Jaguars 7, Colts 3

Indianapolis' first points against Jacksonville this season come after 76:04 of game time. The Colts have gone 105 minutes, 57 seconds of game time since their last touchdown.

The Colts came in scoring touchdowns on 40% of their red zone trips, 30th in the NFL.

Entering second quarter: Colts drive near the red zone

The Colts are at the Jaguars 21-yard line, facing 3rd-and-2. Matt Ryan is 12-of-14 for 100 yards, and Deon Jackson and Michael Pittman Jr. have 4 catches each. Jackson also has 4 carries for 13 yards.

3:48 left 1Q: Jaguars march to the first score

Trevor Lawrence sneaks it in from 1 yard. Jacksonville has 84 rushing yards already. Jaguars 7, Colts 0

A reverse by Jamal Agnew goes for 19 yards to the Colts 1. A screen pass to Travis Etienne goes for 22 yards and to the Colts 20. James Robinson runs for 14 yards.

9:04 left 1Q: Colts get the ball back

DeForest Buckner sacks Trevor Lawrence for a 15-yard loss and out of field goal range. Colts will take over at their 10. The Colts did not sack Lawrence in Week 2.

Travis Etienne rips off a career-long 48-yard run to put Jacksonville at the Colts 25.

Julian Blackmon returns to the roster, but Rodney Thomas II and Rodney McLeod start at safety. Tyquan Lewis starts for the injured Kwity Paye at defensive end.

12:11 left 1Q: Colts come out up-tempo, punt

The Colts drop back to pass on their first 8 plays (1 was a penalty), but they stall at midfield and punt. Matt Ryan goes 6-of-7 for 48 yards. The Colts have not scored on their opening drive this season. Jacksonville gets it at its 15.

12:25 p.m.: Potential Colts starting offensive line

The offensive line has been a major issue. The Colts average 13.8 points per game, worst in the NFL, and they have 1 rushing touchdown.

11:30 a.m.: Colts, Jaguars inactives

Colts: QB Nick Foles, C Wesley French, RB Nyheim Hines, DT Eric Johnson II, LB Shaquille Leonard, DE Kwity Paye, RB Jonathan Taylor. Sam Ehlinger is the backup quarterback. Deon Jackson is the starting running back.

WRs Michael Pittman Jr. and Alec Pierce missed the Week 2 matchup with injuries, but they're back.

Jaguars: DL Folorunso Fatukasi, RB Snoop Conner, S Tyree Gillespie, CB Montaric Brown, WR Marvin Jones Jr., LB De'Shaan Dixon. Jones had 3 catches for 33 yards in Week 2.

Colts vs. Jaguars pregame coverage

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This article originally appeared on Indianapolis Star: Colts vs. Jaguars: NFL live scores, highlights, updates, rankings