Los Angeles Chargers vs. Houston Texans picks, predictions: Who wins NFL Week 4 game?

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The Los Angeles Chargers and Houston Texans play on Sunday in a game on the NFL Week 4 schedule.

Which team will get the victory?

Check out these NFL Week 4 picks and predictions for the game, which can be seen at 10 a.m. MST on CBS.

The Chargers are a 5.5-point favorite in the game.

NFL Week 4 picks, predictions:

The Arizona Republic: Texans 24, Chargers 21

Jeremy Cluff writes: "Call us crazy, but with Justin Herbert not being 100%, we think the Texans can spring the big upset on the Chargers."

Draft Kings: Go with the Chargers to cover against Texans

It writes: "Justin Herbert’s rib injury limited his play in Week 3, and after dropping an unexpected loss to the Jags in part because of those limits, I feel hesitant about the Chargers covering the spread. However, the Texans have lost to much worse teams than Los Angeles already this year, and if Herbert can figure out how to work around the injury, they should be able to win by a touchdown on Sunday."

NFL Week 4 odds:

Top Bet: Chargers 27, Texans 21

It writes: "The Texans are still winless, but they could have easily been 2-1 with a few breaks going their way. Rookie running back Dameon Pierce also finally had a game to remember, albeit in a loss, as for the first time this season, he emerged as the clear leader of Houston’s ground attack, rushing 20 times for 80 yards and a touchdown versus the Bears. He also had two catches for 21 receiving yards. This could be a start of a productive trend for Pierce, who will be taking on the Chargers’ defense that just gave up 151 rushing yards on 36 carries to the Jaguars. The Texans also had five defensive sacks in Week 3, a good trend for them to carry over into Week 4."

Bookies.com: Take the Texans with the points vs. Chargers

Bill Speros writes: "Once again, the Chargers have been unable to match their preseason hype. It may be time for an exorcism on their side of the field in SoFi Stadium after a 38-10 dismantling at the paws of Jaguars in Week 3. The Texans and Chargers finished 2021 both 8-9 ATS. The Texans over-performed with oddsmakers given their 4-13 mark straight-up. They continue to offer value this year are just one of four teams who are 3-0 against the line this season."

More: NFL Week 4 schedule, television information: How to watch Week 4 NFL games

Will Justin Herbert and the Los Angeles Chargers beat the Houston Texans in their NFL Week 4 game?
Will Justin Herbert and the Los Angeles Chargers beat the Houston Texans in their NFL Week 4 game?

Sports Betting Dime: Chargers 22.4, Texans 13.8

The site's formula predicts that the Chargers will win the game against the Texans in NFL Week 4.

Pro Football Network: Go with the Texans with the points against Chargers

BJ Rudell writes: "The Chargers are in trouble at 1-2 and with their franchise QB playing at less than 100%. Just as importantly, Ekeler is averaging a mere 2.5 yards per carry, which is two full yards off his career average. After scoring 20 times last year, Ekeler’s scoreless through three games. The question is whether Houston can stop anyone. While their defense might look pretty good on paper (yielding the 13th-fewest points per game), their three opponents have been a mess offensively. The Colts, Broncos, and Bears are hardly a good test of the Texans’ defensive prowess. Even at less than 100%, the Chargers should prove to be their toughest test."

More: NFL power rankings Week 4: Philadelphia Eagles, Miami Dolphins, Jacksonville Jaguars rise

CBS Sports: Houston has fared well against the spread this season

Tyler Sullivan writes: "Houston is 2-0-1 ATS this season and is 5-0 ATS in its last five games against the AFC. "

ESPN: Chargers have a 70.2% chance to win the game

The site's Football Power Index gives the Texans a 29.5% shot at picking up the victory.

More: NFL Week 4 odds: Point spreads, moneylines, over/under for every Week 4 NFL game

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Los Angeles Chargers vs. Houston Texans picks, predictions NFL Week 4