Has a lot changed since Tennessee Titans played Indianapolis Colts on Oct. 2?

Don't tell Tennessee Titans outside linebacker Bud Dupree an NFL team can't make significant changes over a short amount of time.

Since the Titans faced Indianapolis on Oct. 2, Dupree said the Colts (3-2-1) look a lot different with a rematch coming Sunday (noon, CBS) at Nissan Stadium that could ultimately determine the winner of the AFC South.

"It's different; it looks to me like they're putting the game in (quarterback) Matt Ryan's hands and kind of letting him do his thing," Dupree said Wednesday. "Doing what he's been done his whole career, airing the ball out. He's air raider. At the same time we expect them to be able to come back and run the ball as well."

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The Titans (3-2) gave Ryan trouble in the first game by sacking him three times and intercepting him once in a 24-17 win at Lucas Oil Field.

Last week, however, Ryan was prolific completing a career-high 42 passes on 58 attempts for 389 yards with three touchdowns and no interceptions in a 34-27 win over the Jacksonville Jaguars.

Ryan also passed Pro Football Hall of Fame quarterback Dan Marino for seventh place on the all-time passing yards list with 61,500.

He threw 23 completions to his top two receivers Michael Pittman Jr. (13) and Deon Jackson (10).

A benefit for Tennessee in playing the Colts twice in four weeks is that the Titans are coming off an open week and were able to see the way Ryan played against the Jaguars. The time off for the Titans could also be beneficial because the Colts picked up the tempo on offense and went to a no-huddle attack.

"With us coming off the bye week we had a lot more time to scout ourselves, but also scout the Colts as well," safety Kevin Byard said. "Matt Ryan had a really good game. He threw like 37 times in the first half so we expect them to air it out a little more."

Titans coach Mike Vrabel is confident his team is physically conditioned to handle the game being played at a faster pace. He also believes the Colts' game plan could be much different than what the Titans saw earlier.

"We have to be prepared for things that they've done against us in the past, things that they've tried to modify and change and figure out ways for them to move the ball, which is what they did last week," Vrabel said. "A lot of preparation is going to be on some of the things that they've done well recently and the things that they did well against us that we'll probably see again unless we correct it."

Titans quarterback Ryan Tannehill said the game will have an unusual feel because the two teams played earlier this month.

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"It's just different just because there's not a whole lot of tape in between the two games," said Tannehill, who completed 17-of-21 passes for 137 yards with two touchdowns and no interceptions in the first game. "So there's not as much to study tape-wise, but you're making a lot more adjustments internally."

Vrabel seems to have a knack for getting his team prepared coming off an open date. He is 4-0 in his career in the regular season.

"I think the extra rest certainly helps; I don't think it ever hurts," Vrabel said. "But it comes down to execution, it comes down to the game on Sunday. If Monday was any indication I thought we practiced with good speed and looked like we were rested."

Reach Mike Organ at 615-259-8021 or on Twitter @MikeOrganWriter.

This article originally appeared on Nashville Tennessean: The Tennessee Titans expect big changes from the Indianapolis Colts