Louisville beats UVA football: With Malik Cunningham injured, Brock Domann leads U of L

Last Saturday's 34-33 defeat to Boston College was a stunner for the Louisville football team (2-3, 0-3 ACC).

Not only did the Cards suffer a problematic defeat, but they also lost star quarterback Malik Cunningham for the game. And they won't have him back, either. Louisville confirmed Saturday morning three hours before kickoff Cunningham is unable to go today against Virginia (2-3, 0-2 ACC) while still dealing with a mild concussion. Backup quarterback Brock Domann will get the start.

The matchup against UVA is another chance for the Cardinals to get that first conference win of the season, although that is much harder now without their star quarterback who had started 40 straight games. The Cavaliers are also without a conference win with losses to Syracuse (22-20) and Duke (38-17).

Virginia's passing offense, which was once very dangerous, has tumbled this season. According to ESPN reporter David Hale, UVA quarterback Brennan Armstrong’s QBR dropped from 75.4 in 2021 to 41.2 through five games for a 45.4% decrease.

Louisville football vs. Virginia:Betting line, 3 things to know before making your pick

U of L football:Scott Satterfield will spend more time with Louisville's defense. What that means

Louisville football:Can U of L win an ACC game this season? Ranking their remaining opponents

Be sure to hit REFRESH for the latest updates.

FINAL: Louisville 34, Virginia 17

Louisville quarterback Brock Domann finished with 275 yards passing (17 for 30), one touchdown and two interceptions. He also had nine carries for 71 yards and a score.

Tyler Hudson caught seven passes for 101 yards and a touchdown while Marshon Ford had four catches for 93 yards and a score. Trevion Cooley had 18 carries for 77 yards and a touchdown.

Jawhar Jordan's touchdown extends Louisville's lead - 11:03, Q4

Jawhar Jordan scored on a 1-yard run. Louisville has a comfortable lead at this point.

Louisville 34, Virginia 17

End of the third quarter - Louisville 27, Virginia 17

Trevion Cooley punches in touchdown for Louisville against UVA - 0:54, Q3

Louisville extended its lead after a 1-yard run by Trevion Cooley.

Louisville 27, Virginia 17

Virginia's Brennan Armstrong runs for touchdown, narrows Louisville's lead - 6:58, Q3

Virginia quarterback Brennan Armstrong ran for an 11-yard touchdown to cut Louisville's lead.

Louisville 20, Virginia 17

Brock Domann throws first touchdown pass for Louisville - 10:35, Q3

Louisville quarterback Brock Domman threw a 32-yard pass to Marshon Ford. It was Domman's first TD pass in Cardinal red.

Louisville 20, Virginia 10

HALFTIME: Louisville 13, Virginia 10

Louisville quarterback Brock Domann has completed 8 of 20 pass attempts for 124 yards and two interceptions. He also has ran the ball six times for 59 yards and a score.

Louisville takes the lead over Virginia with a field goal - 0:02 - Q2

James Turner converted a 20-yard field goal to give Louisville the lead over UVA at the half.

Louisville 13, Virginia 10

Louisville quarterback Brock Domann fools the UVA defense with an impressive run - 7:51, Q2

What a play! Louisville quarterback Brock Domann faked a handoff to the running back, then ran around the left side into a wide-open field for a 44-yard touchdown. Things are all tied up.

Louisville 10, Virginia 10

Louisville football gets on the board with a field goal - 10:19, Q2

Louisville kicker James Turner made a 23-yard field goal to put the Cards within reach.

Virginia 10, Louisville 3

End of the third quarter - Virginia 10, Louisville 0

UVA offense fumbles, Louisville will take over - 3:00, Q1

Virginia quarterback Brennan Armstrong ran for 10 yards but fumbled the ball. Louisville defensive lineman Dezmond Tell jumped on the ball to give the Cards' offense a chance to score.

Virginia capitalizes off Louisville interception with touchdown pass - 6:42, Q1

Well, things aren't off to a great start for Louisville football today. Virginia quarterback Brennan Armstrong tossed a 40-yard touchdown to Dontayvion Wicks to cap off a 7-play, 62-yard drive.

Virginia 10, Louisville 0

Louisville's Brock Domann throws interception - 9:37, Q1

Louisville quarterback Brock Domann tossed an interception in the first play of the Cards' second drive. Virginia cornerback Anthony Johnson, who used to play for Louisville, caught the interception.

Virginia takes early lead with field goal - 9:45, Q1

The Virginia Cavaliers struck first in the battle of two teams searching for their first ACC victory. UVA kicker Will Bettridge made a 47-yard field goal to give Virginia the lead.

Earlier in the game, Louisville went three-and-out in its first drive.

Virginia 3, Louisville 0

Louisville Cardinals quarterback Malik Cunningham, running backs Jalen Mitchell, Tiyon Evans out vs. Virginia

The Cardinals confirmed a Sports Illustrated report three hours before kickoff that Cunningham will miss today's game, ending a program-record 40-game streak as the starter. Brock Doman will start in Cunningham's place. Doman is 6 for 16 for 92 yards and an interception this season and completed just one pass last week, for 19 yards, and threw a pick in the fourth quarter as Boston College rallied to beat the Cardinals.

Cunningham is not the only absence. U of L's top two running backs, Jalen Mitchell and Tiyon Evans, are also out. Mitchell has missed a few games, and Tiyon Evans was helped off the field last week with a lower leg injury. And safety Kenderick Duncan is also out, according to pregame reports.

Cunningham, Mitchell out:Brock Domann to start at QB for Cardinals against UVA

How to watch Louisville football vs UVA on TV, livestream

Game time: 12 p.m. ET, Saturday, Oct. 8

Location: Scott Stadium (Charlottesville, Virginia)

TV: ACC Network

Eligible subscribers can also find the game live on Spectrum: 524, Dish: 402 and DirecTV: 612.

Online livestream: WatchESPN

Terrestrial radio broadcast: 93.9-FM/970-AM

Online radio broadcast: GoCards.com

How to watch Louisville vs UVA:Kickoff, TV channel, stream, spread

Louisville vs. Virginia football betting odds

Louisville is favored by 1.5 points after being 2.5-point favorites (last updated Oct. 8) on Tipico Sportsbook. Access USA TODAY Sports’ betting odds for a full list. But other sportsbooks, like BetOnline.ag, now have the Cavaliers as 1-point favorites.

This article originally appeared on Louisville Courier Journal: Louisville football recap: Cards beat Virginia for first ACC win