Merck's Keytruda Plus Chemo Combo Aces Late-Stage Study In Advanced Endometrial Cancer Patients

Vandana Singh
·1 min read
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  • Merck & Co Inc's (NYSE: MRK) Phase 3 NRG-GY018 trial evaluating Keytruda (pembrolizumab) combined with standard-of-care chemotherapy (carboplatin and paclitaxel) met its primary endpoint of progression-free survival (PFS).

  • The trial covered patients with stage III-IV or recurrent endometrial carcinoma regardless of mismatch repair status.

  • Related: Merck's Keytruda Phase 3 Trial Meets Primary Endpoint In Gastric Cancer Patients.

  • The treatment regime included Keytruda + Chemo combo, then continued as a single agent every six weeks for up to 14 cycles.

  • At a pre-specified interim analysis review, the regime demonstrated a statistically significant and clinically meaningful improvement in PFS compared with chemotherapy alone.

  • The safety profile of Keytruda was consistent with that observed in previously reported studies; no new safety signals were identified.

  • This trial was sponsored by the U.S. National Cancer Institute (NCI), part of the National Institutes of Health.

  • Price Action: MRK shares are down 0.63% at $102.81 on the last check Friday.

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This article Merck's Keytruda Plus Chemo Combo Aces Late-Stage Study In Advanced Endometrial Cancer Patients originally appeared on Benzinga.com

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