Lionel Messi's sublime home record for Barcelona makes worrying reading for Napoli, whose task is not nearly as tricky as the one Chelsea face against a Bayern Munich side spearheaded by the sensational Robert Lewandowski.
The final two rearranged Champions League last-16 games take place on Saturday before the competition, which was halted due to the coronavirus pandemic, heads for Lisbon.
Barca, who drew 1-1 at the San Paolo in the first leg, host Napoli for the first time in a competitive match, with Gennaro Gattuso's visitors aiming to become the first team to win their first away trip to Camp Nou since Rubin Kazan in October 2009.
Bayern's squad and coaching team will surely be having their passports stamped for a trip to Portugal having hammered Chelsea 3-0 at Stamford Bridge. Frank Lampard's Blues will have to do something that has never been done if they are to progress.
Barcelona v Napoli
6 - Napoli's Dries Mertens has scored six Champions League goals this season, one shy of the record for goals in a single season in UEFA competition for the club; both Edinson Cavani (2012-13 Europa League) and Gonzalo Higuain (2014-15 Europa League) scored seven each.
11 - Messi has been directly involved in 11 goals in his last five home Champions League knockout matches at Camp Nou (8 goals, 3 assists), scoring a brace in four of those five games.
12 - Barcelona have qualified for the Champions League quarter-finals in each of the last 12 campaigns, last failing in 2006-07 under Frank Rijkaard; no other team has qualified for the last-eight of the competition in more than eight consecutive seasons. They have also progressed from each of their last 19 Champions League knockout ties after avoiding defeat in the first leg away from home, only failing to do so once (vs Juventus in the 2002-03 quarter-final).
2 - Napoli's two previous away Champions League knockout matches have ended in defeat, losing 4-1 to Chelsea in March 2012 and 3-1 to Real Madrid in February 2017. They have failed to progress from nine of their last 10 UEFA European knockout ties when failing to win the first leg.
1 - This is Quique Setien's first home Champions League match as Barcelona boss – 10 of their previous 11 managers have won their first in charge at Camp Nou, with only Louis van Gaal failing to do so in a 2-2 draw against PSV in October 1997.
Bayern Munich v Chelsea
6 - All six of Serge Gnabry's Champions League goals for Bayern this season have come against English teams (four vs Spurs, two vs Chelsea). Only two players have scored more goals against teams from a single nation in one season – Cristiano Ronaldo in 2013-14 vs German teams (7) and Luiz Adriano in 2014-15 vs Belarusian teams (8).
41 - Lewandowski has scored 11 goals and assisted two more in six Champions League appearances this season, averaging a goal or assist every 41 minutes. The German side have failed to win any of their last five knockout stage games in the Champions League in which Lewandowski has not been on the scoresheet (D3 L2).
1- Chelsea have only scored three goals in an away Champions League knockout match once previously, winning 3-1 at Liverpool in April 2009; Bayern have only conceded three times in three of their 43 home Champions League knockout games, though did so most recently in a 3-1 defeat to Liverpool in March 2019.
0 - In the entire history of the European Cup and Champions League, no team has ever won by three or more goals in the first leg of a knockout match away from home and failed to progress, going through on all 92 previous occasions.
3- Bayern Munich manager Hansi Flick is looking to become only the third manager in Champions League history to win his first five matches in charge, after Fabio Capello (first six with Milan in 1992-93) and Luis Fernandez (first six with PSG in 1994-95).