New mural of Tony Hsieh in downtown Las Vegas

There's a brand new mural of former Zappos CEO Tony Hsieh in the lobby of Art Houz Theaters in downtown Las Vegas. The artist, Miguel Hernandez, worked on it ahead of First Friday.

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    Boeing and the Royal Australian Air Force (RAAF) announced Tuesday local time that they've completed the first test flight of a pilotless fighter-like jet devised to operate alongside crewed aircraft.Why it matters: The "Loyal Wingman" combat drone is serving as the foundation for the Boeing Airpower Teaming System being developed for the company's global defense customers. It has the potential to "revolutionize the RAAF's air combat tactics playbook," per The Drive.Get market news worthy of your time with Axios Markets. Subscribe for free.#LoyalWingman has flown into the history books! Together with @AusAirForce, we’ve completed the first test flight for this smart, human-machine team aircraft. pic.twitter.com/oV5qz6AJIu— The Boeing Company (@Boeing) March 2, 2021 The big picture: A Boeing test pilot was monitoring from a ground control station in South Australia's outback during the autonomous plane's flight, according to a joint statement from Boeing and the RAAF.The Australian government has invested US$31 million in the product, which Boeing said previously has drawn interest from countries including the U.S., Reuters notes. It's the first military plane designed and made in Australia in over 50 years.What they're saying: Air Vice-Marshal Cath Roberts, RAAF Head of Air Force Capability, said in a statement, "The Loyal Wingman project is a pathfinder for the integration of autonomous systems and artificial intelligence to create smart human-machine teams."Flashback: Boeing's pilotless vehicle flies for first timeLike this article? Get more from Axios and subscribe to Axios Markets for free.

  • Trump reportedly quietly got his COVID-19 vaccine in January

    Former President Donald Trump never ended up getting his COVID-19 vaccine publicly before he left office — but he reportedly did so off camera. At the Conservative Political Action Conference on Sunday, Trump encouraged supporters to get their COVID-19 vaccine, renewing questions over whether the former president has done so himself. Numerous officials, including former Vice President Mike Pence, got vaccinated on live television as part of an effort to demonstrate to Americans that it's safe. Trump never did so. But The New York Times' Maggie Haberman on Monday reported that according to an adviser, Trump actually did get vaccinated at the White House in January, as did former first lady Melania Trump, even though they didn't say so publicly at the time. The report was confirmed by CNN and Axios. The Los Angeles Times' Chris Megerian noted it was "noteworthy that the former president didn't do this publicly to boost public confidence in the vaccine." Trump yesterday, at CPAC, said for the first time that "everyone" should get the coronavirus vaccine developed while he was in office. An adviser tells me both Trump and Melania Trump got vaccinated at the White House in January. — Maggie Haberman (@maggieNYT) March 1, 2021 In December, then-Surgeon General Jerome Adams said Trump had a "medical reason" for not getting the vaccine yet, as he "received monoclonal antibodies" when he had COVID-19, "and that is actually one scenario where we tell people, 'Maybe you should hold off on getting the vaccine, talk to your health provider to find out the right time.'" CNN's Betsy Klein notes the White House had repeatedly declined to comment when asked if Trump had gotten the vaccine or intended to do so, even "as recently as January 18." After Trump's CPAC speech, The Washington Post's Aaron Blake flagged his comments encouraging his supporters to get vaccinated as "perhaps the most significant thing he said," noting this was "something he avoided forcefully advocating for when he actually commanded the most powerful office in the world." More stories from theweek.comManhattan DA investigators are reportedly focusing on the Trump Organization's chief financial officerHistorian: Biden's support for Amazon workers voting to unionize is 'almost unprecedented'Trump is back. Did anyone miss him?

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  • European Commission raises hopes of coronavirus vaccine passports to ease travel for work and tourism

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  • Chinese vaccines sweep much of the world, despite concerns

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  • There Are 6 Treatments Helping Patients Survive COVID-19

    Carl Court/GettyBy William G. Bain, Georgios D. Kitsios, and Tomeka L. SuberA year ago, when U.S. health authorities issued their first warning that COVID-19 would cause severe “disruption to everyday life,” doctors had no effective treatments to offer beyond supportive care.There is still no cure, but thanks to an unprecedented global research effort, several treatments are helping patients survive COVID-19 and stay out of the hospital altogether.COVID-19 treatments target two broad problems: the coronavirus’s ability to spread through the body, and the damage caused by the body’s immune system response. When the virus enters the body, it takes over cells and uses them to replicate itself. In response, the body sends inflammatory signals and immune cells to fight the virus. In some patients, that inflammatory response can continue even after the virus is under control, leading to damage in the lungs and other organs.The best tool is prevention, including using face masks and vaccines. Vaccines train the immune system to fight off attackers. With less risk of an uncontrolled infection, they can cut the risk of death from COVID-19 to near zero. But vaccine supplies are limited, even with a third vaccine now authorized for U.S. use, so treatments for infected patients remain crucial.This Drug Is a Staple of COVID Treatment. Should It Be?As doctors who work with COVID-19 patients, we have been following the drug trials and success stories. Here are six treatments commonly used today for COVID-19. As you’ll see, timing matters.Keeping you out of the hospitalTwo promising types of treatments involve injecting antiviral antibodies into high-risk COVID-19 patients before the person becomes severely ill.Our bodies naturally create antibodies to recognize foreign invaders and help fight them off. But natural antibody production takes several days, and SARS-CoV-2—the coronavirus that causes COVID-19—replicates fast. Studies show that injecting patients with antibodies soon after symptoms begin can help protect patients against serious infection.Monoclonal antibodies: These lab-engineered antibodies can bind to SARS-CoV-2 and prevent the virus from entering cells and infecting them. They include Bamlanivimab and the combined therapy casirivimab/imdevimab developed by Regeneron. The U.S. Food and Drug Administration granted emergency use authorization for these therapies because they have been found to protect high-risk patients from hospitalization and death. Once patients are sick enough to need hospitalization, however, studies haven’t found a proven benefit from them.Convalescent plasma: Another way to deliver antibodies involves blood drawn from patients who have recovered from COVID-19. Convalescent plasma is primarily given in research settings because the clinical evidence so far is mixed. Some trials show benefits early in the disease. Other studies have not shown any benefit in hospitalized patients.There may be a role for convalescent plasma as a supplemental therapy for some patients because of the growing threat of mutated SARS-CoV-2 variants, which may evade monoclonal antibody therapy. However, careful research is necessary.If you are hospitalizedOnce patients become so sick that they have to be hospitalized, treatments change.Most hospitalized patients have difficulty breathing and low oxygen levels. Low oxygen occurs when the virus and corresponding immune response injure the lungs, resulting in swelling in lung air sacs that restricts the amount of oxygen getting into the blood. Patients hospitalized with COVID-19 usually need supplemental medical oxygen to help them breathe. Doctors frequently treat patients on oxygen with the antiviral agent remdesivir and anti-inflammatory corticosteroids.Remdesivir: Remdesivir, originally designed to treat hepatitis C, stops the coronavirus from replicating itself by interfering with its genetic building blocks. It has been shown to shorten the length of hospital stays, and doctors may prescribe it to patients on oxygen shortly after arrival in the hospital.Chris Christie Says He’s Out of the Hospital After Week-Long Stay for COVID-19Corticosteroids: Steroids calm the body’s immune response and have been used for decades to treat inflammatory disorders. They are also widely available, cheap and well-studied medications, so they were among the first therapies to enter clinical trials for COVID-19. Several studies have shown that low-dose steroids reduce deaths in hospitalized patients who are on oxygen, including the sickest patients in the intensive care unit, or ICU. Following the findings of the landmark RECOVERY and REMAP-CAP COVID-19 studies, steroids are now the standard of care for patients hospitalized with COVID-19 who are treated with oxygen.Blood thinners: Inflammation during COVID-19 and other viral infections can also increase the risk of blood clots, which can cause heart attacks, strokes and dangerous clots in the lungs. Many patients with COVID-19 are given the blood thinners heparin or enoxaparin to prevent clots before they occur. Early data from a large trial of COVID-19 patients suggests that hospitalized patients benefit from higher doses of blood thinners.Some patients with COVID-19 become so sick that they need an ICU for high levels of oxygen support or a ventilator to help them breathe. There are several therapies available for ICU patients, but ICU patients have not been found to benefit from high doses of blood thinners.Treating the sickest patientsICU patients with COVID-19 are more likely to survive if they receive steroids, studies have found. However, low-dose steroids alone may not be enough to curb excessive inflammation.Tocilizumab: Tocilizumab is a lab-generated antibody that blocks the interleukin-6 pathway, which can cause inflammation during COVID-19 and other diseases. New results from the REMAP-CAP trial that have not yet been peer-reviewed suggest that a single dose of tocilizumab given within one to two days after being placed on respiratory support reduced the risk of death in patients already receiving low-dose steroids. Tocilizumab has also been shown to benefit patients with high levels of inflammation in early results from another trial.These innovative therapies can help, but careful supportive care in the ICU is also crucial. Decades of extensive research have defined core management principles for helping patients with severe lung infections who need ventilators. These include avoiding underinflation and overinflation of the lung by the ventilator, treating pain and anxiety with low levels of sedative medications, and periodically placing certain patients with low oxygen levels on their belly, among many other interventions. The same key principles likely apply to patients with COVID-19 to help them survive and recover from a critical illness that can last weeks or months.Medical progress since the start of the pandemic has been awe-inspiring. Doctors now have vaccines, antiviral antibodies for high-risk outpatients and several treatments for hospitalized patients. Continued research will be crucial to improve our ability to fight a disease that has already claimed more than 2.5 million lives worldwide.William G. Bain, Georgios D. Kitsios, and Tomeka L. Suber are assistant professors of medicine at the University of PittsburghRead more at The Daily Beast.Get our top stories in your inbox every day. Sign up now!Daily Beast Membership: Beast Inside goes deeper on the stories that matter to you. Learn more.

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