The Netherlands were expected to qualify out of Group A and did so as group winners following wins over Senegal and Qatar and a draw against Ecuador.
Cody Gakpo has been the breakout star of their World Cup so far with three goals, including the opener in each of their games so far.
The USA battled to second place in Group B in order to reach the last 16. Christian Pulisic scored the crucial goal in their 1-0 win over Iran. Here’s everything you need to know.
When is Netherlands vs USA?
The match will kick off at 3pm GMT (10am ET) on Saturday 3 December. It will be played at the Khalifa International Stadium.
What TV channel is it on and how can I watch it online?
In the UK, it will be shown on BBC One, with coverage starting at 2:30pm, as well as on the BBC iPlayer.
The match will be shown on Fox Sports 1 in the United States.
Netherlands: Noppert; Timber, Van Dijk, Ake; Dumfries, De Roon, F. De Jong, Blind; Klaassen; Gakpo, Depay
USA: Turner; Dest, Zimmerman, Ream, Robinson; Musah, McKennie, Adams; Weah, Pulisic, Ferreira
The Netherlands did not impress during the group stages but you could argue that they have yet to be seriously tested at this World Cup. If they turn it on against the USA, they may prove why they are favourites, but it would still require improvement across all areas. The USA have the energy and gameplan to trouble the Netherlands with their press, which is set to be an important aspect of the match. If they can keep Cody Gakpo quiet and stop Frenkie de Jong from running the game, an upset may be on the cards. Netherlands 0-1 USA