The momager was flooded with messages telling her to contribute to the cause after the Parisian landmark was engulfed in flames on Monday evening.
Sharing an image of the tragic fire, Jenner wrote: “This is just so devastating. My heart goes out to Paris. We grieve for you and pray that in time you can rebuild.
“Thanks to the brave firefighters who have worked so hard, risking their lives, to save the cathedral.”
Jenner was thanked for her support, but others called for her to donate money towards the rebuild.
One user wrote: “You’re a millionaire do something that’ll actually help instead of posting it and saying that your thoughts go out to it lol.”
Another wrote: “Are all the Kardashians going to donate any money to help rebuild it rather than throwing disgustingly lavish parties for babies that are turning 1 and have no clue what's going on? No didn't think so.”
A third hit out: “You could pay for rebuilding it if you are so devastated.”
“Donate money to rebuild it,” posted a fourth.
More than 600 million euros has been pledged by French billionaires and companies to help restore the historic landmark, including Bernard Arnault's family and his LVMH luxury goods group donating 200 million euros.
She added that the price increases if they are asked to advertise “a pharmaceutical product, if it's something that you're going to drink, or ingest, or put on your body”.
The family has seen mass financial success over the years with Forbes naming 21-year-old Kylie America’s youngest self-made billionaire, taking the title from Facebook founder Mark Zuckerberg.