By Deena Beasley (Reuters) - Pfizer Inc's experimental breast cancer drug in a clinical trial nearly doubled the amount of time patients lived without their disease getting worse, but overall survival was not yet shown to be statistically significant, researchers said. The Phase 2 study, which involved women with the most common form of breast cancer, found that those treated with hormone drug letrozole plus Pfizer's palbociclib lived for an average of 20.2 months before their cancer progressed, compared with 10.2 months for patients given letrozole alone. The U.S. Food and Drug Administration has granted "breakthrough" status for palbociclib. Pfizer is still discussing a regulatory pathway for the drug and has not decided whether to seek accelerated approval based on Phase 2 trial results, said Mace Rothenberg, chief medical officer for Pfizer's oncology unit. Palbociclib is viewed as one of the company's most important experimental drugs that some analysts believe could eventually claim annual sales of more than $5 billion, if approved by regulators. The trial tested the pill, which targets proteins involved in cell division, in post-menopausal women with locally advanced or newly diagnosed breast cancer that had spread to other parts of the body. The women had cancer that was both estrogen receptor positive - meaning tumors grow in response to estrogen - and HER2-negative, meaning that the HER2 protein is not causing the cancer. Such patients make up about 60 percent of advanced breast cancer cases. The initial data showed overall survival of 37.5 months for the combination treatment, compared with 33.3 months for patients given just letrozole, an estrogen blocker sold by Novartis AG under the brand name Femara. Researchers said that because only about 30 patients in each arm of the 165-patient trial had died it was still too early to define the drug's impact on survival. "The curves are starting to separate ... It hasn't reached statistical significance, but patients are still being followed," said Dr. Richard Finn, associate professor of medicine at the University of California, Los Angeles, and a lead author of the study. Side effects seen in the trial, including low blood cell counts and fatigue, were manageable, he said in a telephone interview ahead of the study's presentation on Sunday in San Diego at a meeting of the American Association for Cancer Research. Hormonal agents, like Femara, have extended survival for women with estrogen-positive, HER2 negative breast cancer, but there have been no big advances in treatment for nearly two decades, said Dr Judy Garber, a breast cancer specialist at Boston's Dana-Farber Cancer Institute and AACR representative not involved in the palbociclib trial. "This is garden variety breast cancer," she said. "When it recurs, all we really have are other hormonal agents ... This is the first new drug to really show promise." Pfizer is conducting Phase 3 trials in breast cancer patients as well as earlier-stage trials in other types of cancer. Companies trying to develop treatments similar to palbociclib include Novartis and Eli Lilly & Co, which presented Phase 1 data at the AACR meeting. The small trial found that Lilly's drug, LY2835219, used on its own, shrank tumors in 25 percent of women with metastatic estrogen-positive breast cancer, and stabilized the cancer in 55 percent of the same group of women. (Reporting by Deena Beasley; Editing by Anthony Barker)
Our goal is to create a safe and engaging place for users to connect over interests and passions. In order to improve our community experience, we are temporarily suspending article commenting
Angelina Jolie plays Thena — a warrior with immense strength, speed and stamina — in Eternals
Jennifer Gates, the eldest daughter of Bill Gates and Melinda French Gates, celebrated her wedding to Nayel Nassar over the weekend
- Associated Press
A man charged with raping a woman on a commuter train just outside of Philadelphia harassed her for more than 40 minutes while multiple people held up their phones to seemingly record the assault without intervening, authorities said. More than two dozen train stops passed as the man harassed, groped and eventually raped the woman, the police chief for the Southeastern Pennsylvania Transportation Authority said at a news conference Monday. Both the man and woman got on the train at the same stop Wednesday night in North Philadelphia.
- Business Insider
Trump said 'Ku Klux Klan-dressed protesters' who allege they were beaten by his bodyguards have 'no one to blame but themselves'
The deposition concerns a 2015 lawsuit brought by protesters who say they were hit by members of Trump's security detail while at Trump Tower.
- Atlanta Black Star
A California Construction Worker Asked a Speeding Motorist to Slow Down. He Was Shot Seven Times In Response.
The family of a California Black construction worker wants answers after their loved one was shot several times in what is now being looked at […]
- KTNV - Las Vegas Scripps
Las Vegas police are investigating a deadly freeway shooting near McCarran Airport early Monday morning.
- The Daily Beast
Comedy CentralJordan Klepper hadn’t attended a Trump rally since he inadvertently found himself in the middle of the Capitol riot on Jan. 6, “a day no one will ever forget, unless you’re a Republican member of Congress,” the Daily Show contributor joked in his latest dispatch. But this past week, Klepper boldly returned to the scene, trolling the crowd at the former president’s big Iowa event for the most embarrassing devotees he could find.What he discovered more than anything was banners, flag
- Charlotte Observer
It’s just the latest fan incident at Bank of America Stadium to go viral.
- NBC Sports BayArea
Steph Curry is back playing in the Golden State backcourt awaiting Klay Thompsons return. Heres a look at who is starting for the Warriors in 2021.
Tucker Carlson, Will Cain and John Roberts faced backlash for their responses.
- E! News
Nearly two months after hockey player Jimmy Hayes passed away at the age of 31, widow Kristen Hayes said she's "shocked" by his official cause of death. Read on for the details.
He's taking the news "really bad."
- Yahoo News Singapore
A Peruvian female teacher was jailed for seven weeks for throwing killer litter from her 50th-storey unit after
- NBC Sports Boston
After Astros star Carlos Correa pointed to his wrist celebrating a Game 1 home run, a Red Sox fan returned the favor in hilarious fashion during Game 3 of the ALCS at Fenway Park.
On Monday, Hillsborough County Sheriff Chad Chronister announced details of a 20-day long, undercover human trafficking operation that saw 125 men arrested and four women freed.
- Access Hollywood
Kourtney Kardashian and Travis Barker are feeling lots of love from their family and friends after getting engaged. Kourtney confirmed the news on her Instagram page, writing simply “Forever” in her caption alongside two romantic snaps of her and her new fiancé embracing amid a massive display of red roses. Kourtney’s sister Kim Kardashian shared a video on Twitter showing off the Poosh founder’s sparkly engagement ring, writing, “KRAVIS FOREVER” along with an engagement ring emoji.
- CBS News
Madeline Baharlou-Quivey's message said she had strayed from the standard route to Kit Carson Peak.
- Business Insider
Hooters adjusts policy to make controversial new uniform optional for employees after outcry over skimpy new shorts that are 'like underwear'
"We are clarifying that they have the option to choose from traditional uniforms or the new ones," a spokesperson wrote in an email to Insider.
Shanna Moakler posted a bunch of dramatic Instagram Stories after Travis Barker and Kourtney Kardashian's engagement news.
- Business Insider
Fox News anchor John Roberts deleted a tweet that questioned vaccine efficacy in light of Colin Powell's death, clarifying that he is actually pro-vaccine
"The fact that Colin Powell died from a breakthrough COVID infection raises new concerns about how effective vaccines are long-term," he said initially.