Welsh goalkeeper Wayne Hennessey was sent off in the 86th minute for a cynical challenge before the Iranians pounced with the late goals.
Gareth Bale, in his record 110th appearance for his national team, failed to inspired Wales.
With the victory, Iran managed to recover from a humiliating loss against England in their opener. Wales, on the other hand, looked tired after their draw with the United States.
Senegal netted two goals in the 41st and 48th minutes before Qatar struck back in the 78th minute. The Lions of Teranga restored the lead, and claimed all three points, with an 84th-minute goal.
Netherlands 1 - 1 Ecuador
The Netherlands seized an early lead with a Cody Gakpo strike but Ecuador levelled the score with an Enner Valencia goal in the 49th minute.
The Dutch and Ecuadorians are co-leaders in Group A with Senegal also vying for a place in the last 16.
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