Baroness Helena Kennedy QC, a prominent human and civil rights lawyer working in Scotland, said that if the Duke of York were her client she would advise him not to fly to America to speak to the FBI.
The Labour peer, who defended Moors murderer Myra Hindley during a trial in 1974 for attempting to escape from Holloway Prison, warned if the prince was to fly to the US, he might be arrested and unable to leave.
Baroness Kennedy said: "I wouldn't be wanting to send him there because I would be very concerned that suddenly he might be arrested and not able to leave the US.
"I would be very anxious about that."
The Baroness said that the FBI could speak to Prince Andrew in the UK instead, “in the ways that we have of mutual assistance”.
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Speaking to the BBC, the QC said: "If I was his lawyer I would absolutely have advised against him taking part in this interview.
“I would have got a very clear sense that he wasn't going to be able to handle it very well."
She criticised the Duke’s "very weak language" for describing child sex crimes as “unbecoming”, and described his reaction to questions posed by Newsnight journalist Emily Maitlis as “shocking” and “ill-considered”.
Buckingham Palace confirmed today that Prince Andrew would still be able to attend certain high-profile events, including Remembrance Sunday and Trooping the Colour, despite his announcement that he is to stand down from public duties.