Zinedine Zidane's side, who have lost just one league game this season, will remain top of the table with a win.
However, they did stutter recently when knocked out of the Copa del Rey after a stunning performance by Real Sociedad.
Celta Vigo are just two points clear of the relegation zone, however, they come into the fixture riding a wave of momentum after upsetting Sevilla to end their run of eight games without a win.
Here is everything you need to know:
When is it?
The match kicks off at Sunday 16 February.
How can I watch it?
The match will be broadcast live on LaLiga TV.
Real Madrid: Courtois; Carvajal, Varane, Ramos, Mendy; Kroos, Casemiro, Valverde; Isco, Benzema, L Vazquez
Celta Vigo: Blanco; Murillo, Araujo, Aidoo; K Vazquez, Yokuslu, Beltran, Olaza; Rafinha; Aspas, Smolov