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Hunter Biden has accused his father’s opponents of trying to “kill” him in order to destroy the US president’s career.
Mr Biden, 53, said Republicans know his death would be a “pain greater than my father could handle”.
The father of five was speaking to musician Moby in a podcast interview released the day after he was charged with tax crimes.
Mr Biden has also been charged with lying about his drug use while buying a gun in 2018, and has pleaded not guilty.
The recovering drug addict has also been at the centre of an impeachment inquiry into his father by Republicans in the House of Representatives.
Speaking from his art studio in San Francisco, Mr Biden said: “I recognise that none of this is necessarily about me.
“In their most base way, what they’re trying to do is they’re trying to kill me, knowing that it will be a pain greater than my father could be able to handle, and so therefore destroying a presidency in that way.”
‘They are sick people’
He said: “These people are just sad, very, very sick people that have most likely just faced traumas in their lives that they’ve decided that they are going to turn into an evil that they decide that they’re going to inflict on the rest of the world.”
As his 81-year-old father, who has already suffered the deaths of two of his children, campaigns for a second term, Mr Biden acknowledged he is “definitely not in the aftermath” of the attacks against him.
“I’ve stopped hoping for an end to this because as long as my dad is president of the United States, they’re not going to stop,” he said, adding it was “a struggle” to maintain a “well ordered life”.
When asked why he does not defend himself publicly, Mr Biden said he was told it would only add fuel to the fire.
Mr Biden faces three felony tax charges in relation to tax evasion and filing a false return, as well as six misdemeanour charges for failure to pay taxes between 2016 and 2019.