The following post was written and/or published as a collaboration between Benzinga’s in-house sponsored content team and a financial partner of Benzinga.
Salarius Pharmaceuticals Inc. (NASDAQ: SLRX) is developing a novel epigenetics-based treatment that targets the lysine-specific histone demethylase 1 (LSD1) enzyme, which researchers believe plays a key role in the growth of difficult-to-treat cancer cells. Salarius lead drug candidate, seclidemstat, has received Fast Track Designation, Orphan Drug Designation and Rare Pediatric Disease Designation for Ewing sarcoma from the U.S. Food and Drug Administration.
As Salarius works toward getting its pioneering new treatment to market as fast as possible, here’s what Seclidemstat could mean for sarcoma patients and what’s on the horizon for the company.
Sarcoma Patients Struggle with Aggressive Cancers and Limited Treatment Options
Ewing sarcoma is a rare and very deadly cancer that begins in a patient’s bones and primarily affects children and young adults.
While rare, there are about 500 new cases diagnosed in the United States each year. Of those, 40% will not respond to existing first-line treatments, which include chemotherapy, radiation, and surgery, to remove tumors from the bone. For those who don’t see improvements with those first-line treatments or do but then relapse later on, as many as 90% will die within 5 years.
This high mortality rate paired with the fact that Ewing sarcoma primarily affects children and adolescents makes it an urgent priority for cancer researchers around the world.
Other sarcomas, while also rare, feature similar mortality rates and are often equally lacking in effective treatment options. With about 1,500 new cases of myxoid liposarcoma and FET-rearranged sarcomas in the U.S. each year, and a 5-year survival rate ranging from just 16% to 81% depending on how early the cancer was caught, Salarius hopes to get similar regulatory designations to facilitate seclidemstat’s development for the treatment of other sarcomas as well.
As a treatment for Ewing sarcoma alone, Seclidemstat could generate an estimated $200 million in global sales annually, while hoping to significantly improving patient outcomes and quality of life. If approved for myxoid liposarcoma and FET-rearranged sarcoma as well, it could generate an additional $200 million per year.
Salarius Launches new Clinical Trials with Results Anticipated by 2022
Seclidemstat is currently being studied in 2 ongoing clinical trials as part of a treatment combination with chemotherapy agents. Salarius also expanded its clinical programs to study the LSD1 inhibitor’s potential to treat other sarcomas based on encouraging results from preclinical studies and early clinical trial data.
Going forward, the company is enrolling patients in a slate of new clinical trials set to begin later this year. That includes a clinical trial to study Seclidemstat in combination with Keytruda, an antibody-based drug manufactured by Merck & Co. Inc. (NYSE: MRK) to treat gynecological cancers.
Updates from Salarius’s in-progress trials are expected to be announced in the 2nd half of this year with more robust data readouts planned to occur mid-next year. Updates from the trials the company is currently enrolling or planning to initiate soon are expected to be announced by the 2nd half of 2022.
For more information on Salarius, click here.
The preceding post was written and/or published as a collaboration between Benzinga’s in-house sponsored content team and a financial partner of Benzinga. Although the piece is not and should not be construed as editorial content, the sponsored content team works to ensure that any and all information contained within is true and accurate to the best of their knowledge and research. This content is for informational purposes only and not intended to be investing advice.
The author of this piece does not hold shares of any of the companies mentioned. Redington, Inc. employees and members of their families may from time own an equity interest in companies mentioned herein.
The preceding article is sponsored by the clinical communications unit of Redington, Inc, which is paid by Salarius Pharmaceuticals to provide investor communications services. The information contained in this article in no way represents investment advice or opinion on the part of Benzinga or its writers and is intended for informational purposes only.
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