San Francisco 49ers vs. Seattle Seahawks picks, predictions: Who wins NFL Week 15 game?

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The San Francisco 49ers and Seattle Seahawks play on Thursday Night Football in the first game on the NFL Week 15 schedule.

Which team will win the game?

Check out these NFL Week 15 picks and predictions for the game, which can be seen at 6:15 p.m. MST on Amazon Prime Video.

The 49ers are a 3.5-point favorite in the game.

For subscribers:NFL Week 15 picks, predictions: Who wins each Week 15 NFL game?

The Arizona Republic: 49ers 27, Seahawks 20

Jeremy Cluff writes: "The 49ers have won six straight games to earn a 2-game lead in the NFC West. They'll expand that lead on Thursday Night Football."

NFL Week 15 picks: 49ers vs. Seahawks | Colts vs. Vikings | Ravens vs. Browns | Dolphins vs. Bills | Falcons vs. Saints | Steelers vs. Panthers | Eagles vs. Bears | Chiefs vs. Texans | Cowboys vs. Jaguars | Lions vs. Jets | Cardinals vs. Broncos | Patriots vs. Raiders | Titans vs. Chargers | Bengals vs. Buccaneers | Giants vs. Commanders | Rams vs. Packers

Bookies.com: Take the Seahawks with the points vs. 49ers

Bill Speros writes:  "The 49ers turned Purdy into a Baby GOAT against Tampa Bay. The Seahawks were flat-out embarrassed by Carolina. Pete Carroll has got this."

NFL Week 15 odds: 49ers vs. Seahawks | Colts vs. Vikings | Ravens vs. Browns | Dolphins vs. Bills | Falcons vs. Saints | Steelers vs. Panthers | Eagles vs. Bears | Chiefs vs. Texans | Cowboys vs. Jaguars | Lions vs. Jets | Cardinals vs. Broncos | Patriots vs. Raiders | Titans vs. Chargers | Bengals vs. Buccaneers | Giants vs. Commanders | Rams vs. Packers

Will Geno Smith and the Seattle Seahawks beat the San Francisco 49ers on Thursday Night Football in NFL Week 15?
Will Geno Smith and the Seattle Seahawks beat the San Francisco 49ers on Thursday Night Football in NFL Week 15?

ESPN: 49ers have a 63.9% chance to win the game

The site gives the Seahawks a 42.9% chance to get the victory.

Draft Kings: Bet the 49ers to cover vs. Seahawks

It writes: "Normally I’d take the points with Seattle given how wild the NFC West can be. But the 49ers were able to rest some key starters late against the Bucs and I think that will pay off for them on a short week. They’ve got the ground game and defense to grind out a win and that’s what you need on short weeks."

How to watch:NFL Week 15 schedule, television information

Sports Betting Dime: 49ers 27.3, Seahawks 16.5

The site's formula predicts that the 49ers will win the Week 15 NFL game.

OddsChecker: Go with the 49ers to cover vs. Seahawks

It writes: "Brock Purdy couldn’t ask for a better defense to face. Seattle is giving up 28.5 points per game over their last 4. So, we’re combining a red-hot 49ers team looking for their 7th straight win against a team that can’t score against good defenses and can’t defend against anyone? Yeah, hard to take Seattle here even if it is Purdy’s first road game."

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: San Francisco 49ers vs. Seattle Seahawks predictions for NFL Week 15