By Kate Kelland LONDON (Reuters) - British and Japanese scientists have managed to "reset" human stem cells to their earliest state, opening up a new realm of research into the start of human development and potentially life-saving regenerative medicines. In work described by one independent expert as "a major step forward", the scientists said they had successfully rebooted pluripotent stem cells so they were equivalent to those of a 7 to 10-day old embryo, before it implants in the womb. By studying the reset cells, they said they hoped they would now be able to learn more about embryo development, and how it can go wrong and cause miscarriage and developmental disorders. "These cells may represent the real starting point for formation of tissues in the human embryo," said Austin Smith, director of the Britain's Cambridge Stem Cell Institute, who co-led the research published in the journal Cell on Thursday. "We hope that in time they will allow us to unlock the fundamental biology of early development, which is impossible to study directly in people," he added. Human pluripotent stem cells, which have the potential to become any of the cells and tissues in the body, can already be made in a lab either from cells extracted from early-stage embryos or from adult cells that have been induced, or reprogrammed, into an earlier state. But, the researchers said in a statement, until now it has proved difficult to generate human pluripotent stem cells that are at an early enough, pristine stage, before they have started changing. Instead, scientists have only derived cells that are slightly further down the developmental pathway, not a totally "blank slate", said Smith. Experts say that by helping to regenerate tissue, stem cell science could offer new ways of treating conditions for which there are currently no cures - including heart and eye diseases, Parkinson's and stroke. "GOOD NEWS FOR PATIENTS" The process of generating stem cells in the lab is much easier to control in mouse cells, which can be frozen in a state of very early pluripotency using a protein called LIF. Human cells are not as responsive to LIF, so they must be controlled in a different way that involves switching key genes on and off. Smith said this was the main reason why scientists have been unable to generate human pluripotent cells that are as primitive and pristine as their mouse equivalents. To avoid this problem, the scientists introduced two genes – NANOG and KLF2 – which caused a network of genes controlling the cell to reboot and induce the early pluripotent state. Yasuhiro Takashima of the Japan Science and Technology Agency, who worked with Smith, said the reset cells opened the door to a new phase of research. "We now need to carry out further studies to establish how our cells compare with others," he said. "We don't yet know whether these will be a better starting point than existing stem cells for therapies, but being able to start entirely from scratch could prove beneficial." Chris Mason, a stem cell expert and professor of regenerative medicine at University College London who was not involved in this work, praised its results and implications. "Having a source of pristine stem cells which can be precisely changed into clinical-relevant cell types is a major step forward," he said in an emailed comment. "The benefits could be safer and more clinically effective cell therapies produced at lower cost – good news for patients and healthcare providers." (Editing by Andrew Heavens)
- The Independent
McEnany said social media bans were not ‘about stopping violence. This is about stopping Trump, stopping his ideology, his movement, by removing him from society. We should all stand against it’
Brexit campaigner Nigel Farage said on Saturday he would step down as the leader of Reform UK, the rebranded Brexit Party he launched two years ago to campaign for what was commonly known as "no deal Brexit". Farage, who as leader of the eurosceptic UK Independence Party (UKIP) applied pressure on the government to hold the 2016 EU referendum, said the Brexit Party had helped the Conservatives "come to their senses" and chose Boris Johnson as their leader with a pro-Brexit agenda.
- The Independent
Activist group says Ted Cruz and Josh Hawley ‘deserve most blame for firing up violent mob of Trump supporters that attacked US Capitol and killed five people’
Indian farmers began gathering on Saturday to block a six-lane expressway outside New Delhi to mark the 100th day of protests against deregulation of agriculture markets, to add pressure on Prime Minister Narendra Modi's government. Farmers young and old headed in cars, trucks and tractors to the highway for a five-hour roadblock to oppose three farm laws enacted in September 2020 they say hurt them by opening up the agriculture sector to private players. Modi has called the laws much-needed reforms for the country's vast and antiquated agriculture sector, and painted the protests as politically motivated.
The U.S. State Department on Friday said it designated former Ukrainian public official Igor Kolomoisky as ineligible to enter the United States, accusing him of involvement in significant corruption during his time in office. U.S. Secretary of State Antony Blinken in a statement accused Kolomoisky, once the governor of the province of Dnipropetrovsk, close to the border with Russia, of using his office as a governor for personal benefit. "While this designation is based on acts during his time in office, I also want to express concern about Kolomoyskyy’s current and ongoing efforts to undermine Ukraine’s democratic processes and institutions, which pose a serious threat to its future," Blinken said, using another spelling of the Ukrainian's name.
- Associated Press
India routed England by an innings and 25 runs inside three days in the fourth and final test on Saturday and booked a place in the world test championship final against New Zealand. England, trailing by 160 runs, capitulated for 135 in the second innings against the spin duo of Ravichandran Ashwin (5-47) and Axar Patel (5-48) within two sessions on the third day to lose the series 3-1. “Well, we’re obviously happy to win the series, but there are always things to improve,” India captain Virat Kohli said.
- FOX News Videos
Laura Kump, whose mother died in a N.Y. care center in April 2020, says she wants Gov. Andrew Cuomo to admit mistakes were made and be held accountable for them.
- Reuters Videos
Using a clothes line - and a local superstition - as protection, protesters in Yangon gathered behind their makeshift barricades on Saturday (March 6).According to tradition, it's bad luck to pass under these longyis, or sarong-like skirts.And the soldiers believe that, this protester says.Sporadic demonstrations against a month-old military coup were staged across Myanmar.In Yangon, the main city, local media reported security forces used tear gas and stun grenades, just hours after a United Nations special envoy called on the Security Council to take action against the ruling junta for the killings of protesters. More than 50 protesters have been killed since the coup on Feb. 1, according to the U.N.. In a copy of remarks seen by Reuters, UN Special Envoy Christine Schraner Burgener told a closed meeting of the U.N. Security Council on Friday that it must put Myanmar security forces on notice and stand with the people of Myanmar.On Friday night, authorities disturbed the grave of a 19-year-old woman who became an icon of the protest movement after she was shot dead wearing a T-shirt that read "Everything will be OK".According to a witness, the body of Kyal Sin, widely known as Angel, was removed on Friday, examined and returned, before the tomb was re-sealed in the city of Mandalay. A military spokesman did not answer calls seeking comment.Meanwhile, authorities in Myanmar have asked India to return eight policemen who sought refuge across the border to avoid taking orders from the junta, an official in northeast India said on Saturday.India's foreign ministry said in the statement given on Friday that the ministry was still quote "ascertaining the facts."
'Lesson fully received': An 18-year-old charged in the Capitol riot says he was 'wrong' and begged a judge to release him
A Georgia teenager who boasted on Instagram about storming the Capitol in January begged a federal judge to release him ahead of his trial.
- Reuters Videos
Nazih Ghadban is one the few remaining oud makersLocation: Ras Baalbek, LebanonThe 66-year-old luthier has been handcrafting instruments since 1976(SOUNDBITE) (Arabic) LEBANESE OUD MAKER AND PLAYER, NAZIH GHADBAN, SAYING:"I worked on about 1,400 instruments, and I know who each one is with now. I keep a file for each oud, with my notes about the material it is made from and the sound of the oud."Oud is one of the oldest musical instruments in the Middle EastGhadban calls it "the sultan of instruments"(SOUNDBITE) (Arabic) LEBANESE OUD MAKER AND PLAYER, NAZIH GHADBAN, SAYING:"Oud means a lot to me, it's my life companion. I use it in all circumstances, through all the emotions and feelings I go through, in happiness, in sadness, at all the times, I always have the oud."
- Business Insider
"This plan will get checks out the door, starting this month, to the American people who so desperately need the help," Biden said Saturday.
President Biden said Saturday that the Senate passage of his $1.9 trillion COVID relief package means the $1,400 direct payments for most Americans can begin going out later this month. Driving the news: The Senate voted 50-49 Saturday to approve the sweeping legislation. The House is expected to pass the Senate's version of the bill next week before it heads to Biden's desk for his signature.Stay on top of the latest market trends and economic insights with Axios Markets. Subscribe for freeThe big picture: As part of the legislation, individuals who make less than $75,000 or heads of households who make up to $112,500 will qualify for the $1,400 payments. Couples who make less than $150,000 will get $2,800.Individuals who make between $75,000 and $80,000 and couples who earn between $150,000 and $160,000 will receive a reduced payment.Parents who qualify will get an additional $1,400 for every child claimed on their most recent tax returns.What he's saying: "Everything that is in this package is designed to relieve the suffering and meet the most urgent needs of the nation and put us in a better position to prevail," Biden said following the Saturday passage of the bill. "This plan will get checks out the door, starting this month to the American people who so desperately need the help," he added. "The resources in this plan will be used to expand and speed up manufacturing and distribution of vaccines so we can get every single American vaccinated sooner rather than later.""I promised the American people that help is on the way. Today, I can say we've taken one more giant step forward in delivering on that promise." The bottom line: "This plan puts us on a path to beating the virus. This plan gives those families who are struggling the most the help and breathing room to get through this moment. This plan gives small businesses in this country a fighting chance to survive," Biden said. More from Axios: Sign up to get the latest market trends with Axios Markets. Subscribe for free
A Missouri pastor is reportedly seeking 'professional counseling' after he told women to lose weight and strive to be like Melania Trump for their husbands
Pastor Stewart-Allen Clark of Missouri's Malden First General Baptist Church gushed over an "epic trophy wife" and warned, "don't let yourself go."
- The Telegraph
Meghan, Duchess of Sussex 'called all the PR shots', say royal sources despite Oprah interview claims she was gagged
The Duchess of Sussex “called all the shots” when it came to managing her own media, royal sources have said, casting doubt on her claim she could not be interviewed by Oprah Winfrey three years ago. Multiple royal sources have told The Telegraph the 39-year-old former actress “had full control” over her media interviews and had personally forged relationships not only with Ms Winfrey, but other powerful industry figures including Vogue editor Edward Enninful. In a teaser clip released from the Sussexes’s interview with the US chat show host, due to be aired in the US on Sunday, the Duchess said it felt “liberating” to be able to speak and accused the Royal family of effectively gagging her and taking away that choice. “It’s really liberating to be able to have the right and the privilege in some ways to be able to say yes, I’m ready to talk, to be able to make a choice on your own and be able to speak for yourself,” the Duchess said. In the clip, the Duchess and Ms Winfrey reference the fact that a royal aide was listening in to their first phone call in February 2018, although it is understood the pair had spoken privately before then.
Former NBA star Deron Williams says he tried to recruit star players to the Jazz but no one wanted to play in Utah
Deron Williams said he knew he needed help to make the Jazz contenders, but he couldn't find other stars that wanted to join him in Utah.
Even with all the compromises—and the agita on the left—the Covid relief bill may be just what the Democrats needed to deliver.
Past US presidents have left a legacy of untruths ranging from the bizarre to the horrifying.
Kim Kardashian will reportedly stay in family's $60 million mansion as part of divorce from Kanye West
Kim Kardashian West will stay in the minimalist, beige-filled Hidden Hills, California, home she and Kanye West bought in 2014, TMZ reported.
- The New York Times
WASHINGTON — A member of the far-right nationalist Proud Boys was in communication with a person associated with the White House in the days just before the Jan. 6 assault on the Capitol, according to a law enforcement official briefed on the investigation. Location, cellular and call record data revealed a call tying a Proud Boys member to the Trump White House, the official said. The FBI has not determined what they discussed, and the official would not reveal the names of either party. The connection revealed by the communications data comes as the FBI intensifies its investigation of contacts among far-right extremists, Trump White House associates and conservative members of Congress in the days before the attack. Sign up for The Morning newsletter from the New York Times The same data has revealed no evidence of communications between the rioters and members of Congress during the deadly attack, the official said. That undercuts Democratic allegations that some Republican lawmakers were active participants that day. Separately, Enrique Tarrio, a leader of the far-right nationalist Proud Boys, told The New York Times on Friday that he called Roger Stone, a close associate of former President Donald Trump’s, while at a protest in front of the home of Sen. Marco Rubio, R-Fla. During the protest, which occurred in the days before the Capitol assault, he put Stone on speaker phone to address the gathering. A law enforcement official said that it was not Tarrio’s communication with Stone that was being scrutinized, and that the call made in front of Rubio’s home was a different matter. That two members of the group were in communication with people associated with the White House underscores the access that violent extremist groups like the Proud Boys had to the White House and to people close to the former president. Stone denied “any involvement or knowledge of the attack on the Capitol” in a statement last month to the Times. Tarrio was arrested in Washington on Jan. 4 on charges of destruction of property for his role in the burning of a Black Lives Matter banner that had been torn from a historic Black church during a protest in Washington in December. He was asked to leave the city, and was not present when the Capitol was attacked. His case is pending. The Justice Department has charged more than a dozen members of the Proud Boys with crimes related to the attack, including conspiracy to obstruct the final certification of President Joe Biden’s electoral victory and to attack law enforcement officers. In court papers, federal prosecutors have said groups of Proud Boys also coordinated travel to Washington and shared lodging near the city, with the intent of disrupting Congress and advancing Trump’s efforts to unlawfully maintain his grip on the presidency. The communication between the person associated with the White House and the member of the Proud Boys was discovered in part through data that the FBI obtained from technology and telecommunications companies immediately after the assault. Court documents show FBI warrants for a list of all the phones associated with the cell towers serving the Capitol, and that it received information from the major cellphone carriers on the numbers called by everyone on the Capitol’s cell towers during the riot, three officials familiar with the investigation said. The FBI also obtained a “geofence” warrant for all the Android devices that Google recorded within the building during the assault, the officials said. A geofence warrant legally gives law enforcement a list of mobile devices that are able to be identified in a particular geographic area. Jill Sanborn, the head of counterterrorism at the FBI, testified before a Senate panel Wednesday that all the data the FBI had gathered in its investigation into the riot was obtained legally through subpoenas and search warrants. Although investigators have found no contact between the rioters and members of Congress during the attack, those records have shown evidence in the days leading up to Jan. 6 of communications between far-right extremists and lawmakers who were planning to appear at the rally featuring Trump that occurred just before the assault, according to one of the officials. The Justice Department is examining those communications, but it has not opened investigations into any members, the official said. A department spokesperson declined to comment. The FBI did, however, say Thursday that it had arrested a former State Department aide on charges related to the attack, including unlawful entry, violent and disorderly conduct, obstructing Congress and law enforcement, and assaulting an officer with a dangerous weapon. The former midlevel aide, Federico Klein, who was seen in videos assaulting officers with a stolen riot shield, was the first member of the Trump administration to face criminal charges in connection with the storming of the Capitol. His lawyer declined to comment Friday. Right-wing extremists, including members of the Oath Keepers, a militia group that mainly comprises former law enforcement and military personnel, have been working as security guards for Republicans and for Trump’s allies, such as Stone. Stone, who was pardoned by Trump after refusing to cooperate with the investigation into the Trump campaign’s contacts with Russian intelligence, has known Tarrio for some time and used Oath Keepers as bodyguards before and on the day of the assault on the Capitol. The Justice Department is looking into communications between Stone and far-right extremists to determine whether he played any role in plans by extremists to disrupt the certification on Jan. 6, according to two people familiar with the matter who were not authorized to speak about the investigation. Should investigators find messages showing that Stone had any connection to such plans, they would have a factual basis to open a full criminal investigation into him, the people said. Stone said last month that he was “provided voluntary security by the Oath Keepers,” but noted that their security work did not constitute evidence that he was involved in, or informed about, plans to attack Congress. He reiterated an earlier statement that anyone involved in the attack should be prosecuted. The Justice Department has charged more than 300 people with crimes stemming from the Jan. 6 assault. It has used evidence gathered in its broad search for assailants — including information from cellular providers and technology companies — to help piece together evidence of more sophisticated crimes, like conspiracy. It is also looking at possible charges of seditious conspiracy, according to two people familiar with the investigation. This article originally appeared in The New York Times. © 2021 The New York Times Company
A Texas middle school student said he was forced to drink urine by teammates at a sleepover. His mom called the bullying racially motivated.
Summer Smith, SeMarion Humphrey's mom, says she has reported multiple incidents of her son being abused by other students for months, CBS 21 reported.