A 10ft python has been found in a Cambridgeshire country lane, with the RSPCA urging people to stay vigilant in case there are more.
The snake was discovered in Conington on Monday, days after an earlier snake sighting in the same village at the end of last week.
Both animals are likely to be abandoned or escaped pets, the RSPCA said, adding that they are at risk from cold weather and harvesting in nearby fields.
RSPCA inspector Justin Stubbs likened the first incident, in which a "huge snake" was rescued from up a tree, to the Disney film The Jungle Book. The second snake was seen "crossing a quiet country lane", the animal charity said.
Mr Stubbs said: "Having rescued last Friday's python, I couldn't believe it when the call came through to say there had been another found in almost exactly the same spot.
"I'm afraid that's no coincidence – it's looking likely these poor animals were abandoned, or have escaped from the same place. This second snake was extremely cold when he was found, very much thinner than the first python, which is suffering from a minor health condition.
"Both snakes are now being looked after at a specialist facility and are under heat lamps to maintain a healthy body temperature. It is really concerning to think that someone has kept these pythons, then might have decided to abandon them in this cruel and callous way. I only hope that there are no more on the loose out there."
Mr Stubbs also urged people in the area to stay vigilant "in case there are more vulnerable snakes found in the same spot".
The RSPCA said the snakes are "unlikely to pose any danger to people", but recommended that anyone who sees an exotic snake should keep a safe distance. The charity is asking anyone with information about the incident to call its appeal line on 0300 123 8018.