News of the woman in Chicago infected with the virus followed the announcement earlier this week of a man from Washington state who was diagnosed with the virus after returning from Wuhan.
The newly discovered virus has killed 26 people and infected more than 800.
Most of the cases and all of the deaths so far have been in China, where officials have imposed severe restrictions on travel and public gatherings.
The virus has created alarm, but there are a still many unknowns surrounding it, such as just how dangerous it is and how easily it spreads between people. It can lead to pneumonia, which has been deadly in some cases.
The woman from Chicago had traveled to Wuhan in December and returned Jan. 13.
Arwady said the woman is in stable condition and remains in an unnamed Chicago hospital primarily for infection control purposes. The woman had not taken public transportation and was not ill when she traveled, Arwady said.