Sorrento's Human Derived Mesenchymal Stem Cells Achieves 100% Discharge Rate In Critically-Ill COVID-19 Patients

Vandana Singh
·1 min read
  • Sorrento Therapeutics Inc (NASDAQ: SRNE) has announced data from its Phase 1b study of human allogeneic adipose-derived mesenchymal stem cells (COVI-MSC) infusions to treat COVID-19 induced acute respiratory failure (ARD) or acute respiratory distress syndrome (ARDS).

  • The study met its primary objective to demonstrate the safety of intravenous infusion of allogeneic adipose MSC cells in patients with COVID-19-induced ARD or ARDS.

  • Subjects were administered COVI-MSCs every other day for up to three infusions for a total of 1 x 106 cells/kg, with patients being followed for 28 days following the final infusion.

  • A total of 10 patients were enrolled, and all were discharged from the hospital to home within three days of their last infusion.

  • At baseline, all patients required oxygen supplementation. All patients had various medical co-morbidities in addition to obesity.

  • The 10th patient had been under treatment for nearly two weeks without improvement and was discharged after the second COVI-MSC infusion.

  • Sorrento will be working with the FDA shortly once the whole dataset is available to plan a placebo-controlled pivotal study to support an emergency use authorization submission.

  • Price Action: SRNE shares are up 2.3% at $7.66 in market hours on the last check Tuesday.

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