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The now-deleted post featured a split-screen image of Reid, 50, with and without makeup: "Thank god for makeup", the anonymous user wrote and cc'd Reid and her co-presenter Piers Morgan.
Reid simply replied "Hallelujah!" Which prompted her fans to defend her on Twitter.
"Susanna, with or without makeup you're a very beautiful gorgeous women, you truly are, I've said this many times in the past years. You prove it every time I see you, you get more so with age and your personality matches your loveliness," posted John Horne, who was one of more than 100 comments on the post.
"Your '4am' is supermodel to my '2hrs with a glam squad' at any time of the day & we're the same vintage!" Said Kath Wilson.
"You are beautiful Regardless," said Adam Goode in a post under the tweet.
"You are beautiful with and without makeup Susanna," said user Bex.
Fans have often commented on how Reid has seemingly defied the process of ageing, in 2020 she shared a clip of her from 20 years ago as a new reader, one Twitter user said: "You looked older then than now!.. well played!!"
"I thought if I had a crop and I didn’t look in the least bit glamorous, I’d look exceptionally serious,” Reid said to Fabulous magazine about her style from two decades ago.
Previously Reid has cited sobriety as a reason her skin is in good condition. “My skin isn't perfect but it's clearer. And so is my head. I am sleeping better."
In an interview last week with The Sunday Times the presenter said she gave up alcohol on advice from the doctor. "I was concerned because my skin was flushed, I kept getting flare-ups and blemishes, and they were leaving red scars.
"I’d tried all manner of creams and washes, but I knew deep down that what was happening to my skin was probably a manifestation of what I was putting into my body."