Which team will win the game?
Check out these NFL Week 14 picks and predictions for the game, which can be seen at 2:25 p.m. MST on Fox.
The 49ers are a 3.5-point favorite in the game.
For subscribers:NFL Week 14 picks, predictions: Who wins each Week 14 NFL game?
The Arizona Republic: 49ers 21, Buccaneers 14
Jeremy Cluff writes: "It's Brock Purdy time in San Francisco, but the rookie QB thankfully has an amazing defense to help him out."
NFL Week 14 picks: Raiders vs. Rams | Jets vs. Bills | Browns vs. Bengals | Texans vs. Cowboys | Vikings vs. Lions | Eagles vs. Giants | Ravens vs. Steelers | Jaguars vs. Titans | Chiefs vs. Broncos | Panthers vs. Seahawks | Buccaneers vs. 49ers | Dolphins vs. Chargers | Patriots vs. Cardinals
Bookies.com: Take the Buccaneers on the moneyline vs. 49ers
Bill Speros writes: "This game had all the makings of a late-season, nationally-televised thriller. And one that would have been very easy on the eyes. Tom Brady was set to face another former teammate in Jimmy Garoppolo. The GOAT vs. the LAMB. Not anymore. Jimmy G. broke his foot in San Francisco's 33-17 win and cover (-5) against Miami."
NFL Week 14 odds: Raiders vs. Rams | Jets vs. Bills | Browns vs. Bengals | Texans vs. Cowboys | Vikings vs. Lions | Eagles vs. Giants | Ravens vs. Steelers | Jaguars vs. Titans | Chiefs vs. Broncos | Panthers vs. Seahawks | Buccaneers vs. 49ers | Dolphins vs. Chargers | Patriots vs. Cardinals
ESPN: Buccaneers have a 51.2% chance to win the game
The site gives the 49ers a 48.2% chance to get the victory.
CBS Sports: 49ers favored vs. Buccaneers
Tyler Sullivan writes: "San Francisco is 4-1 ATS over its last five games and is 4-2 ATS at home this season. Meanwhile, the Bucs are 2-3 ATS on the road."
How to watch:NFL Week 14 schedule, television information
Sports Betting Dime: 49ers 16.5, Buccaneers 7.4
The site's formula predicts that the 49ers will win the Week 14 NFL game.
OddsChecker: Go with the Buccaneers with the points vs. 49ers
It writes: "This game is going to be low scoring, but one side has a 7th round rookie and the other side has Tom Brady. If this is going to be a tight low scoring game, then it’s hard to pick the rookie over the best QB in the history of the NFL."
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This article originally appeared on Arizona Republic: Tampa Bay Buccaneers vs. San Francisco 49ers picks for NFL Week 14